The Endocannabinoid System and Its Role in Eczematous Dermatoses

Alexandra R. Trusler, Ashley K. Clark, Raja K Sivamani, Vivian Y. Shi

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

The skin serves as the foremost barrier between the internal body and the external world, providing crucial protection against pathogens and chemical, mechanical, and ultraviolet damages. The skin is a central player in the intricate network of immune, neurologic, and endocrine systems. The endocannabinoid system (ECS) includes an extensive network of bioactive lipid mediators and their receptors, functions to modulate appetite, pain, mood, and memory, and has recently been implicated in skin homeostasis. Disruption of ECS homeostasis is implicated in the pathogenesis of several prevalent skin conditions. In this review, we highlight the role of endocannabinoids in maintaining skin health and homeostasis and discuss evidence on the role of ECS in several eczematous dermatoses including atopic dermatitis, asteatotic eczema, irritant contact dermatitis, allergic contact dermatitis, and chronic pruritus. The compilation of evidence may spark directions for future investigations on how the ECS may be a therapeutic target for dermatologic conditions.

Original languageEnglish (US)
Pages (from-to)22-32
Number of pages11
JournalDermatitis
Volume28
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Endocannabinoids
Skin Diseases
Skin
Homeostasis
Irritant Dermatitis
Endocrine System
Allergic Contact Dermatitis
Eczema
Contact Dermatitis
Appetite
Atopic Dermatitis
Pruritus
Nervous System
Immune System
Lipids
Pain
Health

ASJC Scopus subject areas

  • Immunology and Allergy
  • Dermatology

Cite this

The Endocannabinoid System and Its Role in Eczematous Dermatoses. / Trusler, Alexandra R.; Clark, Ashley K.; Sivamani, Raja K; Shi, Vivian Y.

In: Dermatitis, Vol. 28, No. 1, 01.01.2017, p. 22-32.

Research output: Contribution to journalReview article

Trusler, Alexandra R. ; Clark, Ashley K. ; Sivamani, Raja K ; Shi, Vivian Y. / The Endocannabinoid System and Its Role in Eczematous Dermatoses. In: Dermatitis. 2017 ; Vol. 28, No. 1. pp. 22-32.
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