The emerging role of the androgen receptor in bladder cancer

Alan P. Lombard, Maria Mudryj

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Men are three to four times more likely to get bladder cancer than women. The gender disparity characterizing bladder cancer diagnoses has been investigated. One hypothesis is that androgen receptor (AR) signaling is involved in the etiology and progression of this disease. Although bladder cancer is not typically described as an endocrine-related malignancy, it has become increasingly clear that AR signaling plays a role in bladder tumors. This review summarizes current findings regarding the role of the AR in bladder cancer. We discuss work demonstrating AR expression in bladder cancer and its role in promoting formation and progression of tumors. Additionally, we discuss the therapeutic potential of targeting the AR in this disease.

Original languageEnglish (US)
Pages (from-to)R265-R277
JournalEndocrine-Related Cancer
Volume22
Issue number5
DOIs
StatePublished - Oct 1 2015

Keywords

  • Androgen receptor
  • Bladder cancer
  • Endocrine therapy

ASJC Scopus subject areas

  • Endocrinology
  • Oncology
  • Cancer Research
  • Endocrinology, Diabetes and Metabolism

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