Objective: To determine if perioperative steroid therapy benefits pediatric primary palatoplasty patients. Design: A prospective, double- blind, randomized trial with a placebo control. Setting: An academic medical center. Patients: Forty-five children undergoing primary repair of their cleft palate between 1989 and 1996 who were under the age of 48 months and without developmental delay or any associated syndrome. Interventions: Intravenous dexamethasone sodium phosphate (0.25 mg/kg) or a placebo (5% dextrose in water) immediately preoperatively and once every 8 hours for two doses postoperatively. Main outcome measures: Postoperative airway distress, fever, oral fluid intake, discharge eligibility, and palatal fistula formation. Results: Perioperative steroid therapy significantly reduced the incidence of postoperative airway distress (p = .05) and postoperative fever (p = .02); postoperative oral fluid intake, discharge eligibility, and palatal fistula formation were not significantly affected. Conclusions: Perioperative steroids effectively lower the risk of postoperative airway distress and postoperative fever in children undergoing the primary repair of their cleft palate. This finding favors a customary role for perioperative steroid therapy in pediatric primary palatoplasty.
|Original language||English (US)|
|Number of pages||5|
|Journal||Cleft Palate-Craniofacial Journal|
|State||Published - Jul 1999|
- Perioperative steroid therapy
- Primary palatoplasty
ASJC Scopus subject areas