The efficacy of perioperative steroid therapy in pediatric primary palatoplasty

Craig W Senders, Stephen M. Di Mauro, Hilary A Brodie, Brian E. Emery, Jonathan M Sykes

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: To determine if perioperative steroid therapy benefits pediatric primary palatoplasty patients. Design: A prospective, double- blind, randomized trial with a placebo control. Setting: An academic medical center. Patients: Forty-five children undergoing primary repair of their cleft palate between 1989 and 1996 who were under the age of 48 months and without developmental delay or any associated syndrome. Interventions: Intravenous dexamethasone sodium phosphate (0.25 mg/kg) or a placebo (5% dextrose in water) immediately preoperatively and once every 8 hours for two doses postoperatively. Main outcome measures: Postoperative airway distress, fever, oral fluid intake, discharge eligibility, and palatal fistula formation. Results: Perioperative steroid therapy significantly reduced the incidence of postoperative airway distress (p = .05) and postoperative fever (p = .02); postoperative oral fluid intake, discharge eligibility, and palatal fistula formation were not significantly affected. Conclusions: Perioperative steroids effectively lower the risk of postoperative airway distress and postoperative fever in children undergoing the primary repair of their cleft palate. This finding favors a customary role for perioperative steroid therapy in pediatric primary palatoplasty.

Original languageEnglish (US)
Pages (from-to)340-344
Number of pages5
JournalCleft Palate-Craniofacial Journal
Volume36
Issue number4
DOIs
StatePublished - Jul 1999

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Steroids
Pediatrics
Fever
dexamethasone 21-phosphate
Cleft Palate
Fistula
Placebos
Therapeutics
Outcome Assessment (Health Care)
Glucose
Water
Incidence

Keywords

  • Perioperative steroid therapy
  • Primary palatoplasty

ASJC Scopus subject areas

  • Surgery
  • Dentistry(all)

Cite this

The efficacy of perioperative steroid therapy in pediatric primary palatoplasty. / Senders, Craig W; Di Mauro, Stephen M.; Brodie, Hilary A; Emery, Brian E.; Sykes, Jonathan M.

In: Cleft Palate-Craniofacial Journal, Vol. 36, No. 4, 07.1999, p. 340-344.

Research output: Contribution to journalArticle

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