The effects of oral agent or insulin treatments on the plasma lipoproteins and the plasma lipoprotein lipase activator in diabetic patients

Siddika E Karakas, R. C. LeBoeuf, M. J. Rockett, J. Page, A. J. Keyser

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The structure and the metabolism of plasma lipoproteins are altered in diabetes mellitus. Insulin or oral agent treatments affect the lipoprotein metabolism in addition to improving hyperglycemia. However, it is not clear whether the alterations seen in lipoproteins during treatment are related to the degree of diabetic control or to the mode of diabetic treatment. The effects of insulin or oral agent treatments on the plasma lipoproteins and lipoprotein lipase activator were compared in a strictly defined non-obese, non-insulin dependent diabetic patient. Both treatment groups had similar plasma triglyceride, total cholesterol, low and high density lipoprotein cholesterol, and lipoprotein lipase activator levels. Lipoprotein lipase activator contents of the very low density lipoproteins correlated positively with their triglyceride (r = 0.803 in insulin, r = 0.828 in oral agent treated patients) and protein (r = 0.713 in insulin, r = 0.862 in oral agent treated patients) contents. The findings of this study indicated that plasma lipid levels, very low density lipoprotein compositions, and lipoprotein lipase activator contents were not significantly different in non-obese, non-insulin dependent diabetic patients treated with either oral hypoglycemic agents or insulin.

Original languageEnglish (US)
Pages (from-to)190-193
Number of pages4
JournalHormone and Metabolic Research
Volume18
Issue number3
StatePublished - 1986
Externally publishedYes

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Lipoprotein Lipase Activators
Lipoproteins
Insulin
Plasmas
VLDL Lipoproteins
Proxy
Metabolism
Triglycerides
Therapeutics
Cholesterol
Medical problems
Hypoglycemic Agents
Hyperglycemia
LDL Cholesterol
HDL Cholesterol
Diabetes Mellitus
Lipids
Chemical analysis

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

The effects of oral agent or insulin treatments on the plasma lipoproteins and the plasma lipoprotein lipase activator in diabetic patients. / Karakas, Siddika E; LeBoeuf, R. C.; Rockett, M. J.; Page, J.; Keyser, A. J.

In: Hormone and Metabolic Research, Vol. 18, No. 3, 1986, p. 190-193.

Research output: Contribution to journalArticle

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AB - The structure and the metabolism of plasma lipoproteins are altered in diabetes mellitus. Insulin or oral agent treatments affect the lipoprotein metabolism in addition to improving hyperglycemia. However, it is not clear whether the alterations seen in lipoproteins during treatment are related to the degree of diabetic control or to the mode of diabetic treatment. The effects of insulin or oral agent treatments on the plasma lipoproteins and lipoprotein lipase activator were compared in a strictly defined non-obese, non-insulin dependent diabetic patient. Both treatment groups had similar plasma triglyceride, total cholesterol, low and high density lipoprotein cholesterol, and lipoprotein lipase activator levels. Lipoprotein lipase activator contents of the very low density lipoproteins correlated positively with their triglyceride (r = 0.803 in insulin, r = 0.828 in oral agent treated patients) and protein (r = 0.713 in insulin, r = 0.862 in oral agent treated patients) contents. The findings of this study indicated that plasma lipid levels, very low density lipoprotein compositions, and lipoprotein lipase activator contents were not significantly different in non-obese, non-insulin dependent diabetic patients treated with either oral hypoglycemic agents or insulin.

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