Abstract
The influence of manganese deficiency on liver trace element concentration, MnSOD activity, and mitochondrial structure and function during postnatal development was determined in rats. In both normal and manganese-deficient animals, liver manganese concentration increased with time, but in deficient rats liver manganese was lower than in controls at all ages measured. At 9 mo of age, liver manganese concentration in the deficient rats was only 20% that of controls. The developmental pattern observed for MnSOD paralleled that of liver manganese concentration in normal and deficient rats; it was lower than in controls on days 20 and 60. However, at 9 mo of age, MnSOD levels were similar in the two groups. Although there were no differences at 9 mo of age in MnSOD activity between the groups, manganese-deficient rats showed mitochondrial abnormalities in liver. Despite mitochondrial abnormalities, however, oxygen uptake and P/O ratios were normal. We suggest that the mitochondrial damage apparent at 9 mo of age is, at least in part, the result of lower than normal MnSOD activity occurring earlier. The functional significance of the abnormalities remains to be established.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 31-48 |
| Number of pages | 18 |
| Journal | Biological Trace Element Research |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1985 |
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Keywords
- and mitochondrial functions
- development, and trace elements, in rats
- lipid peroxidation, and Mn deficiency
- Manganese, and mitochondrial functions
- mitochondrial function, in Mn deficient rats
- MnSOD
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry, medical
- Inorganic Chemistry
- Clinical Biochemistry
- Biochemistry
Cite this
The effects of manganese deficiency during prenatal and postnatal development on mitochondrial structure and function in the rat. / Zidenberg-Cherr, Sheri; Keen, Carl L; Hurley, Lucille S.
In: Biological Trace Element Research, Vol. 7, No. 1, 02.1985, p. 31-48.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effects of manganese deficiency during prenatal and postnatal development on mitochondrial structure and function in the rat
AU - Zidenberg-Cherr, Sheri
AU - Keen, Carl L
AU - Hurley, Lucille S.
PY - 1985/2
Y1 - 1985/2
N2 - The influence of manganese deficiency on liver trace element concentration, MnSOD activity, and mitochondrial structure and function during postnatal development was determined in rats. In both normal and manganese-deficient animals, liver manganese concentration increased with time, but in deficient rats liver manganese was lower than in controls at all ages measured. At 9 mo of age, liver manganese concentration in the deficient rats was only 20% that of controls. The developmental pattern observed for MnSOD paralleled that of liver manganese concentration in normal and deficient rats; it was lower than in controls on days 20 and 60. However, at 9 mo of age, MnSOD levels were similar in the two groups. Although there were no differences at 9 mo of age in MnSOD activity between the groups, manganese-deficient rats showed mitochondrial abnormalities in liver. Despite mitochondrial abnormalities, however, oxygen uptake and P/O ratios were normal. We suggest that the mitochondrial damage apparent at 9 mo of age is, at least in part, the result of lower than normal MnSOD activity occurring earlier. The functional significance of the abnormalities remains to be established.
AB - The influence of manganese deficiency on liver trace element concentration, MnSOD activity, and mitochondrial structure and function during postnatal development was determined in rats. In both normal and manganese-deficient animals, liver manganese concentration increased with time, but in deficient rats liver manganese was lower than in controls at all ages measured. At 9 mo of age, liver manganese concentration in the deficient rats was only 20% that of controls. The developmental pattern observed for MnSOD paralleled that of liver manganese concentration in normal and deficient rats; it was lower than in controls on days 20 and 60. However, at 9 mo of age, MnSOD levels were similar in the two groups. Although there were no differences at 9 mo of age in MnSOD activity between the groups, manganese-deficient rats showed mitochondrial abnormalities in liver. Despite mitochondrial abnormalities, however, oxygen uptake and P/O ratios were normal. We suggest that the mitochondrial damage apparent at 9 mo of age is, at least in part, the result of lower than normal MnSOD activity occurring earlier. The functional significance of the abnormalities remains to be established.
KW - and mitochondrial functions
KW - development, and trace elements, in rats
KW - lipid peroxidation, and Mn deficiency
KW - Manganese, and mitochondrial functions
KW - mitochondrial function, in Mn deficient rats
KW - MnSOD
UR - http://www.scopus.com/inward/record.url?scp=0022391477&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022391477&partnerID=8YFLogxK
U2 - 10.1007/BF02916545
DO - 10.1007/BF02916545
M3 - Article
AN - SCOPUS:0022391477
VL - 7
SP - 31
EP - 48
JO - Biological Trace Element Research
JF - Biological Trace Element Research
SN - 0163-4984
IS - 1
ER -