The effects of lesions of superior temporal gyrus and inferior parietal lobe on temporal and vertex components of the human AEP

Robert T. Knight, Donatella Scabini, David L Woods, Clay Clayworth

Research output: Contribution to journalArticle

150 Citations (Scopus)

Abstract

We recorded auditory evoked potentials (AEPs) to 1 kHz tone bursts in controls and patients with unilateral lesions centered in posterior superior temporal gyrus and adjacent caudal inferior parietal lobule (STG) or in rostral inferior parietal lobule (IPL). Controls generated a vertex maximal N94 (N1b) and P200 (P2) and additional P45, N78 and N127 temporal AEP components (P45, N1a, N1c). Similar to prior reports, in controls the N1a was most prominent over the left temporal lobe and the P45 was largest over the right temporal lobe consistent with behavioral and anatomical data indicating differential organization of left and right human temporal lobe. The N1c was recorded equally from both T3 and T4 electrodes and was enhanced in the temporal site contralateral to the ear of stimulation. The patient groups had differenti al effects on AEPs. Unilateral STG lesions resulted in bilateral reductions of the N1b and P45 and marked unilateral reductions of the N1a and N1c over lesioned hemisphere. IPL lesions resulted in bilateral but non-significant reductions of the N1b and N1c. The scalp topography results in normal subjects combined with the effects of unilateral STG lesions provide supportive evidence that the temporal maximal components of the human AEP (P45, N1a, N1c) are generated by radially oriented neuronal dipole sources located in STG. The bilateral reduction of the N1b vertex response by unilateral STG lesions is compatible with a unilateral disruption of a vertically oriented dipole situated in the posterior superior temporal plane. The results emphasize the critical role of the superior temporal plane and lateral superior temporal gyrus in generation of human long latency AEPs.

Original languageEnglish (US)
Pages (from-to)499-509
Number of pages11
JournalElectroencephalography and Clinical Neurophysiology
Volume70
Issue number6
DOIs
StatePublished - 1988

Fingerprint

Auditory Evoked Potentials
Parietal Lobe
Temporal Lobe
Scalp
Ear
Electrodes
Organizations

Keywords

  • AEPs
  • Parietal lobe
  • T-complex
  • Temporal lobe
  • Vertex potential

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

The effects of lesions of superior temporal gyrus and inferior parietal lobe on temporal and vertex components of the human AEP. / Knight, Robert T.; Scabini, Donatella; Woods, David L; Clayworth, Clay.

In: Electroencephalography and Clinical Neurophysiology, Vol. 70, No. 6, 1988, p. 499-509.

Research output: Contribution to journalArticle

@article{cb725f23f5c242b193698704411169ea,
title = "The effects of lesions of superior temporal gyrus and inferior parietal lobe on temporal and vertex components of the human AEP",
abstract = "We recorded auditory evoked potentials (AEPs) to 1 kHz tone bursts in controls and patients with unilateral lesions centered in posterior superior temporal gyrus and adjacent caudal inferior parietal lobule (STG) or in rostral inferior parietal lobule (IPL). Controls generated a vertex maximal N94 (N1b) and P200 (P2) and additional P45, N78 and N127 temporal AEP components (P45, N1a, N1c). Similar to prior reports, in controls the N1a was most prominent over the left temporal lobe and the P45 was largest over the right temporal lobe consistent with behavioral and anatomical data indicating differential organization of left and right human temporal lobe. The N1c was recorded equally from both T3 and T4 electrodes and was enhanced in the temporal site contralateral to the ear of stimulation. The patient groups had differenti al effects on AEPs. Unilateral STG lesions resulted in bilateral reductions of the N1b and P45 and marked unilateral reductions of the N1a and N1c over lesioned hemisphere. IPL lesions resulted in bilateral but non-significant reductions of the N1b and N1c. The scalp topography results in normal subjects combined with the effects of unilateral STG lesions provide supportive evidence that the temporal maximal components of the human AEP (P45, N1a, N1c) are generated by radially oriented neuronal dipole sources located in STG. The bilateral reduction of the N1b vertex response by unilateral STG lesions is compatible with a unilateral disruption of a vertically oriented dipole situated in the posterior superior temporal plane. The results emphasize the critical role of the superior temporal plane and lateral superior temporal gyrus in generation of human long latency AEPs.",
keywords = "AEPs, Parietal lobe, T-complex, Temporal lobe, Vertex potential",
author = "Knight, {Robert T.} and Donatella Scabini and Woods, {David L} and Clay Clayworth",
year = "1988",
doi = "10.1016/0013-4694(88)90148-4",
language = "English (US)",
volume = "70",
pages = "499--509",
journal = "Electroencephalography and Clinical Neurophysiology",
issn = "0013-4694",
publisher = "Elsevier BV",
number = "6",

}

TY - JOUR

T1 - The effects of lesions of superior temporal gyrus and inferior parietal lobe on temporal and vertex components of the human AEP

AU - Knight, Robert T.

AU - Scabini, Donatella

AU - Woods, David L

AU - Clayworth, Clay

PY - 1988

Y1 - 1988

N2 - We recorded auditory evoked potentials (AEPs) to 1 kHz tone bursts in controls and patients with unilateral lesions centered in posterior superior temporal gyrus and adjacent caudal inferior parietal lobule (STG) or in rostral inferior parietal lobule (IPL). Controls generated a vertex maximal N94 (N1b) and P200 (P2) and additional P45, N78 and N127 temporal AEP components (P45, N1a, N1c). Similar to prior reports, in controls the N1a was most prominent over the left temporal lobe and the P45 was largest over the right temporal lobe consistent with behavioral and anatomical data indicating differential organization of left and right human temporal lobe. The N1c was recorded equally from both T3 and T4 electrodes and was enhanced in the temporal site contralateral to the ear of stimulation. The patient groups had differenti al effects on AEPs. Unilateral STG lesions resulted in bilateral reductions of the N1b and P45 and marked unilateral reductions of the N1a and N1c over lesioned hemisphere. IPL lesions resulted in bilateral but non-significant reductions of the N1b and N1c. The scalp topography results in normal subjects combined with the effects of unilateral STG lesions provide supportive evidence that the temporal maximal components of the human AEP (P45, N1a, N1c) are generated by radially oriented neuronal dipole sources located in STG. The bilateral reduction of the N1b vertex response by unilateral STG lesions is compatible with a unilateral disruption of a vertically oriented dipole situated in the posterior superior temporal plane. The results emphasize the critical role of the superior temporal plane and lateral superior temporal gyrus in generation of human long latency AEPs.

AB - We recorded auditory evoked potentials (AEPs) to 1 kHz tone bursts in controls and patients with unilateral lesions centered in posterior superior temporal gyrus and adjacent caudal inferior parietal lobule (STG) or in rostral inferior parietal lobule (IPL). Controls generated a vertex maximal N94 (N1b) and P200 (P2) and additional P45, N78 and N127 temporal AEP components (P45, N1a, N1c). Similar to prior reports, in controls the N1a was most prominent over the left temporal lobe and the P45 was largest over the right temporal lobe consistent with behavioral and anatomical data indicating differential organization of left and right human temporal lobe. The N1c was recorded equally from both T3 and T4 electrodes and was enhanced in the temporal site contralateral to the ear of stimulation. The patient groups had differenti al effects on AEPs. Unilateral STG lesions resulted in bilateral reductions of the N1b and P45 and marked unilateral reductions of the N1a and N1c over lesioned hemisphere. IPL lesions resulted in bilateral but non-significant reductions of the N1b and N1c. The scalp topography results in normal subjects combined with the effects of unilateral STG lesions provide supportive evidence that the temporal maximal components of the human AEP (P45, N1a, N1c) are generated by radially oriented neuronal dipole sources located in STG. The bilateral reduction of the N1b vertex response by unilateral STG lesions is compatible with a unilateral disruption of a vertically oriented dipole situated in the posterior superior temporal plane. The results emphasize the critical role of the superior temporal plane and lateral superior temporal gyrus in generation of human long latency AEPs.

KW - AEPs

KW - Parietal lobe

KW - T-complex

KW - Temporal lobe

KW - Vertex potential

UR - http://www.scopus.com/inward/record.url?scp=0023793967&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023793967&partnerID=8YFLogxK

U2 - 10.1016/0013-4694(88)90148-4

DO - 10.1016/0013-4694(88)90148-4

M3 - Article

C2 - 2461284

AN - SCOPUS:0023793967

VL - 70

SP - 499

EP - 509

JO - Electroencephalography and Clinical Neurophysiology

JF - Electroencephalography and Clinical Neurophysiology

SN - 0013-4694

IS - 6

ER -