The effects of intracameral carbachol on post-operative intraocular pressure rises after cataract extraction in the dog

C. M. Stuhr, P. E. Miller, Christopher J Murphy, J. V. Schoster

Research output: Contribution to journalArticle

Abstract

Purpose. We previously have demonstrated ciliary cleft collapse as a component of the acute post-operative rise in IOP in dogs following phacoemulsification lens extraction (Invest Ophthalmol Vis Sci 1994, 35:419). The purpose of this study was to determine if intracameral carbachol at the conclusion of cataract extraction would blunt the elevation in IOP in the early post-operative period. Methods. A randomized, placebo-controlled, masked trial was performed using thirty-one dogs which were assigned into four groups: 1) posterior chamber IOL placement with 0.5 ml of BSS, 2) PC IOL with 0.5 ml of 0.01% carbachol, 3) aphakic with 0.5 ml BSS, and 4) aphakic with 0.5 ml of 0.01% carbachol. IOP was measured by applanation tonometry and intraocular inflammation was evaluated by slit lamp biomicroscopy at 3, 6, and 24 hrs post-operatively. Results. Twelve of 31 dogs, none of whom received carbachol, had a post-operative pressure rise > 27 mmHg (range 29-61 mmHg; mean 43 mmHg). Seven were pseudophakic, and five were aphakic. Intraocular pressure spikes were recorded at the 3 hr period in all dogs that exhibited an elevation in IOP. No differences in the degree of post-operative intraocular inflammation was observed in any group. Conclusions. Intracameral injection of carbachol significantly prevented postoperative IOP spikes in the dog following phacoemulsification lens extraction, in both pseudophakic and aphakic patients, without deleterious effects.

Original languageEnglish (US)
JournalInvestigative Ophthalmology and Visual Science
Volume38
Issue number4
StatePublished - 1997
Externally publishedYes

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Cataract Extraction
Carbachol
Intraocular Pressure
Dogs
Phacoemulsification
Lenses
Inflammation
Manometry
Placebos
Pressure
Injections

ASJC Scopus subject areas

  • Ophthalmology

Cite this

The effects of intracameral carbachol on post-operative intraocular pressure rises after cataract extraction in the dog. / Stuhr, C. M.; Miller, P. E.; Murphy, Christopher J; Schoster, J. V.

In: Investigative Ophthalmology and Visual Science, Vol. 38, No. 4, 1997.

Research output: Contribution to journalArticle

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abstract = "Purpose. We previously have demonstrated ciliary cleft collapse as a component of the acute post-operative rise in IOP in dogs following phacoemulsification lens extraction (Invest Ophthalmol Vis Sci 1994, 35:419). The purpose of this study was to determine if intracameral carbachol at the conclusion of cataract extraction would blunt the elevation in IOP in the early post-operative period. Methods. A randomized, placebo-controlled, masked trial was performed using thirty-one dogs which were assigned into four groups: 1) posterior chamber IOL placement with 0.5 ml of BSS, 2) PC IOL with 0.5 ml of 0.01{\%} carbachol, 3) aphakic with 0.5 ml BSS, and 4) aphakic with 0.5 ml of 0.01{\%} carbachol. IOP was measured by applanation tonometry and intraocular inflammation was evaluated by slit lamp biomicroscopy at 3, 6, and 24 hrs post-operatively. Results. Twelve of 31 dogs, none of whom received carbachol, had a post-operative pressure rise > 27 mmHg (range 29-61 mmHg; mean 43 mmHg). Seven were pseudophakic, and five were aphakic. Intraocular pressure spikes were recorded at the 3 hr period in all dogs that exhibited an elevation in IOP. No differences in the degree of post-operative intraocular inflammation was observed in any group. Conclusions. Intracameral injection of carbachol significantly prevented postoperative IOP spikes in the dog following phacoemulsification lens extraction, in both pseudophakic and aphakic patients, without deleterious effects.",
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AU - Schoster, J. V.

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N2 - Purpose. We previously have demonstrated ciliary cleft collapse as a component of the acute post-operative rise in IOP in dogs following phacoemulsification lens extraction (Invest Ophthalmol Vis Sci 1994, 35:419). The purpose of this study was to determine if intracameral carbachol at the conclusion of cataract extraction would blunt the elevation in IOP in the early post-operative period. Methods. A randomized, placebo-controlled, masked trial was performed using thirty-one dogs which were assigned into four groups: 1) posterior chamber IOL placement with 0.5 ml of BSS, 2) PC IOL with 0.5 ml of 0.01% carbachol, 3) aphakic with 0.5 ml BSS, and 4) aphakic with 0.5 ml of 0.01% carbachol. IOP was measured by applanation tonometry and intraocular inflammation was evaluated by slit lamp biomicroscopy at 3, 6, and 24 hrs post-operatively. Results. Twelve of 31 dogs, none of whom received carbachol, had a post-operative pressure rise > 27 mmHg (range 29-61 mmHg; mean 43 mmHg). Seven were pseudophakic, and five were aphakic. Intraocular pressure spikes were recorded at the 3 hr period in all dogs that exhibited an elevation in IOP. No differences in the degree of post-operative intraocular inflammation was observed in any group. Conclusions. Intracameral injection of carbachol significantly prevented postoperative IOP spikes in the dog following phacoemulsification lens extraction, in both pseudophakic and aphakic patients, without deleterious effects.

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