The Effects of Glucosamine and Chondroitin Sulfate on Gut Microbial Composition: A Systematic Review of Evidence from Animal and Human Studies

Anna Shmagel, Ryan Demmer, Daniel Knights, Mary Butler, Lisa Langsetmo, Nancy E Lane, Kristine Ensrud

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Oral glucosamine sulfate (GS) and chondroitin sulfate (CS), while widely marketed as joint-protective supplements, have limited intestinal absorption and are predominantly utilized by gut microbiota. Hence the effects of these supplements on the gut microbiome are of great interest, and may clarify their mode of action, or explain heterogeneity in therapeutic responses. We conducted a systematic review of animal and human studies reporting the effects of GS or CS on gut microbial composition. We searched MEDLINE, EMBASE, and Scopus databases for journal articles in English from database inception until July 2018, using search terms microbiome, microflora, intestinal microbiota/flora, gut microbiota/flora and glucosamine or chondroitin. Eight original articles reported the effects of GS or CS on microbiome composition in adult humans (four articles) or animals (four articles). Studies varied significantly in design, supplementation protocols, and microbiome assessment methods. There was moderate-quality evidence for an association between CS exposure and increased abundance of genus Bacteroides in the murine and human gut, and low-quality evidence for an association between CS exposure and an increase in Desulfovibrio piger species, an increase in Bacteroidales S24-7 family, and a decrease in Lactobacillus. We discuss the possible metabolic implications of these changes for the host. For GS, evidence of effects on gut microbiome was limited to one low-quality study. This review highlights the importance of considering the potential influence of oral CS supplements on gut microbiota when evaluating their effects and safety for the host.

Original languageEnglish (US)
JournalNutrients
Volume11
Issue number2
DOIs
StatePublished - Jan 30 2019

Fingerprint

chondroitin sulfate
Chondroitin Sulfates
glucosamine
Glucosamine
systematic review
intestinal microorganisms
Microbiota
animals
digestive system
Desulfovibrio piger
mouth
flora
Bacteroides
Desulfovibrio
intestinal absorption
Chondroitin
Databases
joints (animal)
Lactobacillus
Gastrointestinal Microbiome

Keywords

  • chondroitin
  • glucosamine
  • microbiome

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

The Effects of Glucosamine and Chondroitin Sulfate on Gut Microbial Composition : A Systematic Review of Evidence from Animal and Human Studies. / Shmagel, Anna; Demmer, Ryan; Knights, Daniel; Butler, Mary; Langsetmo, Lisa; Lane, Nancy E; Ensrud, Kristine.

In: Nutrients, Vol. 11, No. 2, 30.01.2019.

Research output: Contribution to journalReview article

Shmagel, Anna ; Demmer, Ryan ; Knights, Daniel ; Butler, Mary ; Langsetmo, Lisa ; Lane, Nancy E ; Ensrud, Kristine. / The Effects of Glucosamine and Chondroitin Sulfate on Gut Microbial Composition : A Systematic Review of Evidence from Animal and Human Studies. In: Nutrients. 2019 ; Vol. 11, No. 2.
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