Abstract
Biodegradable implants that release growth factors or other bioactive agents in a controlled manner are investigated to enhance the repair of musculoskeletal tissues. In this study, the in vitro release characteristics and mechanical properties of a 50:50 polylactic acid/polyglycolic acid two phase implant were examined over a 6-week period under no-load conditions or under a cyclic compressive load, such as that experienced when walking slowly during rehabilitation. The results demonstrated that a cyclic compressive load significantly slows the decrease of molecular chain size during the first week, significantly increases protein release for the first 2-3 weeks, and significantly stiffens the implant for the first 3 weeks. It was also shown that protein release is initially high and steadily decreases with time until the molecular weight declines to about 20% of its original value (approximately 4 weeks). Once this threshold is reached, increased protein release, surface deformation, and mass loss occurs. This study also showed that dynamic loading and the environment in which an implant is placed affect its biodegradation. Therefore, it may be essential that in vitro degradation studies of these or similar implants include a dynamic functional environment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 61-74 |
| Number of pages | 14 |
| Journal | Tissue Engineering |
| Volume | 2 |
| Issue number | 1 |
| State | Published - 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biophysics
- Cell Biology
Cite this
The effects of dynamic compressive loading on biodegradable implants of 50-50% polylactic acid-polyglycolic acid. / Thompson, Douglas E.; Mauli Agrawal, C.; Athanasiou, Kyriacos.
In: Tissue Engineering, Vol. 2, No. 1, 1996, p. 61-74.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effects of dynamic compressive loading on biodegradable implants of 50-50% polylactic acid-polyglycolic acid
AU - Thompson, Douglas E.
AU - Mauli Agrawal, C.
AU - Athanasiou, Kyriacos
PY - 1996
Y1 - 1996
N2 - Biodegradable implants that release growth factors or other bioactive agents in a controlled manner are investigated to enhance the repair of musculoskeletal tissues. In this study, the in vitro release characteristics and mechanical properties of a 50:50 polylactic acid/polyglycolic acid two phase implant were examined over a 6-week period under no-load conditions or under a cyclic compressive load, such as that experienced when walking slowly during rehabilitation. The results demonstrated that a cyclic compressive load significantly slows the decrease of molecular chain size during the first week, significantly increases protein release for the first 2-3 weeks, and significantly stiffens the implant for the first 3 weeks. It was also shown that protein release is initially high and steadily decreases with time until the molecular weight declines to about 20% of its original value (approximately 4 weeks). Once this threshold is reached, increased protein release, surface deformation, and mass loss occurs. This study also showed that dynamic loading and the environment in which an implant is placed affect its biodegradation. Therefore, it may be essential that in vitro degradation studies of these or similar implants include a dynamic functional environment.
AB - Biodegradable implants that release growth factors or other bioactive agents in a controlled manner are investigated to enhance the repair of musculoskeletal tissues. In this study, the in vitro release characteristics and mechanical properties of a 50:50 polylactic acid/polyglycolic acid two phase implant were examined over a 6-week period under no-load conditions or under a cyclic compressive load, such as that experienced when walking slowly during rehabilitation. The results demonstrated that a cyclic compressive load significantly slows the decrease of molecular chain size during the first week, significantly increases protein release for the first 2-3 weeks, and significantly stiffens the implant for the first 3 weeks. It was also shown that protein release is initially high and steadily decreases with time until the molecular weight declines to about 20% of its original value (approximately 4 weeks). Once this threshold is reached, increased protein release, surface deformation, and mass loss occurs. This study also showed that dynamic loading and the environment in which an implant is placed affect its biodegradation. Therefore, it may be essential that in vitro degradation studies of these or similar implants include a dynamic functional environment.
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M3 - Article
C2 - 19877952
AN - SCOPUS:8944259446
VL - 2
SP - 61
EP - 74
JO - Tissue Engineering
JF - Tissue Engineering
SN - 1076-3279
IS - 1
ER -