The effects of doxapram, diazepam, phenobarbital and pentylenetetrazol on suprathreshold and threshold stimulations in amygdaloid kindled rats

Timothy E Albertson, L. G. Stark, R. M. Joy

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Amygdaloid kindled rats were utilized to determine the effects of the respiratory stimulant doxapram (7.5-60 mg/kg) on seizures elicited by suprathreshold or threshold electrical stimulation. For comparison, a single dose of pentylenetetrazol (30 mg/kg), phenobarbital (40 mg/kg) and diazepam (2 mg/kg) were also tested in the same paradigm. With suprathreshold stimulation, doxapram did not increase the intensity of seizures. Neither the afterdischarge duration (AD) nor the behavioral rank (BR) were increased with doses high enough to cause systemic signs of toxicity. Similarly, the convulsant pentylenetetrazol did not increase AD or BR after suprathreshold stimulation. The anticonvulsants phenobarbital and diazepam significantly reduced both AD and BR after suprathreshold stimulation. Seizure thresholds tended to be higher after the various doses of doxapram with no consistent effect on elicited AD or BR. Pentylenetetrazol did not change threshold values, but was found to increase AD and BR at threshold. Both phenobarbital and diazepam raised thresholds with a significant decrease in elicited AD and BR. It would appear that the respiratory stimulant doxapram has little proconvulsant activity in this model of epilepsy.

Original languageEnglish (US)
Pages (from-to)245-248
Number of pages4
JournalNeuropharmacology
Volume22
Issue number2
DOIs
StatePublished - 1983

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Fingerprint Dive into the research topics of 'The effects of doxapram, diazepam, phenobarbital and pentylenetetrazol on suprathreshold and threshold stimulations in amygdaloid kindled rats'. Together they form a unique fingerprint.

  • Cite this