The effects of CO2 pneumoperitoneum on hemodynamics in hemorrhaged animals

Hung S Ho, C. J. Saunders, F. A. Corso, B. M. Wolfe, J. Van de Water, T. G. Buchman, D. J. Dries, W. S. Helton, Santora, P. J. Fabri

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Abstract

Background. Carbon dioxide (CO2), the primary gas currently used for pneumoperitoneum, has been known to cause systemic effects on acid-base balance and hemodynamic stability. We studied the hemodynamic effects of CO2 pneumoperitoneum in a hemorrhagic shock model to assess the safety of laparoscopic procedures in acute trauma patients. Methods. After 1 hour of baseline, 32 anesthetized adult pigs were randomized into four groups. Group 1 animals had no hemorrhage, serving as a control group. Group 2 animals had a mild hemorrhage of 10 ml/kg/hr. Group 3 animals had a moderate hemorrhage of 20 ml/kg/hr. Group 4 animals had a moderate hemorrhage but were resuscitated with 40 ml/kg of lactated Ringer's solution. All animals were then insufflated to an intraabdominal pressure of 15 mm Hg with CO2 gas for 1 hour. The abdomen was then decompressed, and the animals were observed for another hour. All animals survived hemorrhage. One death each occurred in moderate hemorrhage groups, both near the end of CO2 pneumoperitoneum. These animals were not included in statistical analysis. Results. In euvolemic animals, CO2 pneumoperitoneum induced hypercapnia (from 34 ± 1 mm Hg to 48 ± 1 mm Hg), acidemia (from 7.45 ± 0.02 to 7.36 ± 0.02), and a 20% reduction in stroke volume. Mild hemorrhage and CO2 insufflation resulted in a similar degree of acidemia (7.35 ± 0.01), but moderate hemorrhage and CO2 insufflation led to more severe acidemia (7.26 ± 0.02). Fluid resuscitation failed to prevent this severe fall in pH (7.30 ± 0.03) for group 4. PaCO2 was not affected by hemorrhage, but CO2 pneumoperitoneum induced significant hypercapnia in all groups, ranging from 48 ± 1 mm Hg for euvolemic animals to 52 ± 1 mm Hg for moderate hemorrhage animals. Stroke volume declined as a function of blood loss, and it was further depressed by CO2 insufflation, to as low as 75% of baseline in mild hemorrhage and 55% of baseline in moderate hemorrhage. Both stroke volume and cardiac index initially responded to large-volume fluid replacement after moderate hemorrhage but quickly decreased to levels comparable to those of unresuscitated animals when CO2 pneumoperitoneum was created. Conclusions. Intraperitoneal insufflation with CO2 for diagnostic laparoscopy may be hazardous in acute hypovolemic trauma patients.

Original languageEnglish (US)
Pages (from-to)381-388
Number of pages8
JournalSurgery
Volume114
Issue number2
StatePublished - 1993

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Pneumoperitoneum
Hemodynamics
Hemorrhage
Insufflation
Stroke Volume
Hypercapnia
Gases
Hypovolemia
Acid-Base Equilibrium
Hemorrhagic Shock
Wounds and Injuries
Carbon Dioxide
Resuscitation
Abdomen
Laparoscopy

ASJC Scopus subject areas

  • Surgery

Cite this

Ho, H. S., Saunders, C. J., Corso, F. A., Wolfe, B. M., Van de Water, J., Buchman, T. G., ... Fabri, P. J. (1993). The effects of CO2 pneumoperitoneum on hemodynamics in hemorrhaged animals. Surgery, 114(2), 381-388.

The effects of CO2 pneumoperitoneum on hemodynamics in hemorrhaged animals. / Ho, Hung S; Saunders, C. J.; Corso, F. A.; Wolfe, B. M.; Van de Water, J.; Buchman, T. G.; Dries, D. J.; Helton, W. S.; Santora; Fabri, P. J.

In: Surgery, Vol. 114, No. 2, 1993, p. 381-388.

Research output: Contribution to journalArticle

Ho, HS, Saunders, CJ, Corso, FA, Wolfe, BM, Van de Water, J, Buchman, TG, Dries, DJ, Helton, WS, Santora & Fabri, PJ 1993, 'The effects of CO2 pneumoperitoneum on hemodynamics in hemorrhaged animals', Surgery, vol. 114, no. 2, pp. 381-388.
Ho HS, Saunders CJ, Corso FA, Wolfe BM, Van de Water J, Buchman TG et al. The effects of CO2 pneumoperitoneum on hemodynamics in hemorrhaged animals. Surgery. 1993;114(2):381-388.
Ho, Hung S ; Saunders, C. J. ; Corso, F. A. ; Wolfe, B. M. ; Van de Water, J. ; Buchman, T. G. ; Dries, D. J. ; Helton, W. S. ; Santora ; Fabri, P. J. / The effects of CO2 pneumoperitoneum on hemodynamics in hemorrhaged animals. In: Surgery. 1993 ; Vol. 114, No. 2. pp. 381-388.
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title = "The effects of CO2 pneumoperitoneum on hemodynamics in hemorrhaged animals",
abstract = "Background. Carbon dioxide (CO2), the primary gas currently used for pneumoperitoneum, has been known to cause systemic effects on acid-base balance and hemodynamic stability. We studied the hemodynamic effects of CO2 pneumoperitoneum in a hemorrhagic shock model to assess the safety of laparoscopic procedures in acute trauma patients. Methods. After 1 hour of baseline, 32 anesthetized adult pigs were randomized into four groups. Group 1 animals had no hemorrhage, serving as a control group. Group 2 animals had a mild hemorrhage of 10 ml/kg/hr. Group 3 animals had a moderate hemorrhage of 20 ml/kg/hr. Group 4 animals had a moderate hemorrhage but were resuscitated with 40 ml/kg of lactated Ringer's solution. All animals were then insufflated to an intraabdominal pressure of 15 mm Hg with CO2 gas for 1 hour. The abdomen was then decompressed, and the animals were observed for another hour. All animals survived hemorrhage. One death each occurred in moderate hemorrhage groups, both near the end of CO2 pneumoperitoneum. These animals were not included in statistical analysis. Results. In euvolemic animals, CO2 pneumoperitoneum induced hypercapnia (from 34 ± 1 mm Hg to 48 ± 1 mm Hg), acidemia (from 7.45 ± 0.02 to 7.36 ± 0.02), and a 20{\%} reduction in stroke volume. Mild hemorrhage and CO2 insufflation resulted in a similar degree of acidemia (7.35 ± 0.01), but moderate hemorrhage and CO2 insufflation led to more severe acidemia (7.26 ± 0.02). Fluid resuscitation failed to prevent this severe fall in pH (7.30 ± 0.03) for group 4. PaCO2 was not affected by hemorrhage, but CO2 pneumoperitoneum induced significant hypercapnia in all groups, ranging from 48 ± 1 mm Hg for euvolemic animals to 52 ± 1 mm Hg for moderate hemorrhage animals. Stroke volume declined as a function of blood loss, and it was further depressed by CO2 insufflation, to as low as 75{\%} of baseline in mild hemorrhage and 55{\%} of baseline in moderate hemorrhage. Both stroke volume and cardiac index initially responded to large-volume fluid replacement after moderate hemorrhage but quickly decreased to levels comparable to those of unresuscitated animals when CO2 pneumoperitoneum was created. Conclusions. Intraperitoneal insufflation with CO2 for diagnostic laparoscopy may be hazardous in acute hypovolemic trauma patients.",
author = "Ho, {Hung S} and Saunders, {C. J.} and Corso, {F. A.} and Wolfe, {B. M.} and {Van de Water}, J. and Buchman, {T. G.} and Dries, {D. J.} and Helton, {W. S.} and Santora and Fabri, {P. J.}",
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T1 - The effects of CO2 pneumoperitoneum on hemodynamics in hemorrhaged animals

AU - Ho, Hung S

AU - Saunders, C. J.

AU - Corso, F. A.

AU - Wolfe, B. M.

AU - Van de Water, J.

AU - Buchman, T. G.

AU - Dries, D. J.

AU - Helton, W. S.

AU - Santora,

AU - Fabri, P. J.

PY - 1993

Y1 - 1993

N2 - Background. Carbon dioxide (CO2), the primary gas currently used for pneumoperitoneum, has been known to cause systemic effects on acid-base balance and hemodynamic stability. We studied the hemodynamic effects of CO2 pneumoperitoneum in a hemorrhagic shock model to assess the safety of laparoscopic procedures in acute trauma patients. Methods. After 1 hour of baseline, 32 anesthetized adult pigs were randomized into four groups. Group 1 animals had no hemorrhage, serving as a control group. Group 2 animals had a mild hemorrhage of 10 ml/kg/hr. Group 3 animals had a moderate hemorrhage of 20 ml/kg/hr. Group 4 animals had a moderate hemorrhage but were resuscitated with 40 ml/kg of lactated Ringer's solution. All animals were then insufflated to an intraabdominal pressure of 15 mm Hg with CO2 gas for 1 hour. The abdomen was then decompressed, and the animals were observed for another hour. All animals survived hemorrhage. One death each occurred in moderate hemorrhage groups, both near the end of CO2 pneumoperitoneum. These animals were not included in statistical analysis. Results. In euvolemic animals, CO2 pneumoperitoneum induced hypercapnia (from 34 ± 1 mm Hg to 48 ± 1 mm Hg), acidemia (from 7.45 ± 0.02 to 7.36 ± 0.02), and a 20% reduction in stroke volume. Mild hemorrhage and CO2 insufflation resulted in a similar degree of acidemia (7.35 ± 0.01), but moderate hemorrhage and CO2 insufflation led to more severe acidemia (7.26 ± 0.02). Fluid resuscitation failed to prevent this severe fall in pH (7.30 ± 0.03) for group 4. PaCO2 was not affected by hemorrhage, but CO2 pneumoperitoneum induced significant hypercapnia in all groups, ranging from 48 ± 1 mm Hg for euvolemic animals to 52 ± 1 mm Hg for moderate hemorrhage animals. Stroke volume declined as a function of blood loss, and it was further depressed by CO2 insufflation, to as low as 75% of baseline in mild hemorrhage and 55% of baseline in moderate hemorrhage. Both stroke volume and cardiac index initially responded to large-volume fluid replacement after moderate hemorrhage but quickly decreased to levels comparable to those of unresuscitated animals when CO2 pneumoperitoneum was created. Conclusions. Intraperitoneal insufflation with CO2 for diagnostic laparoscopy may be hazardous in acute hypovolemic trauma patients.

AB - Background. Carbon dioxide (CO2), the primary gas currently used for pneumoperitoneum, has been known to cause systemic effects on acid-base balance and hemodynamic stability. We studied the hemodynamic effects of CO2 pneumoperitoneum in a hemorrhagic shock model to assess the safety of laparoscopic procedures in acute trauma patients. Methods. After 1 hour of baseline, 32 anesthetized adult pigs were randomized into four groups. Group 1 animals had no hemorrhage, serving as a control group. Group 2 animals had a mild hemorrhage of 10 ml/kg/hr. Group 3 animals had a moderate hemorrhage of 20 ml/kg/hr. Group 4 animals had a moderate hemorrhage but were resuscitated with 40 ml/kg of lactated Ringer's solution. All animals were then insufflated to an intraabdominal pressure of 15 mm Hg with CO2 gas for 1 hour. The abdomen was then decompressed, and the animals were observed for another hour. All animals survived hemorrhage. One death each occurred in moderate hemorrhage groups, both near the end of CO2 pneumoperitoneum. These animals were not included in statistical analysis. Results. In euvolemic animals, CO2 pneumoperitoneum induced hypercapnia (from 34 ± 1 mm Hg to 48 ± 1 mm Hg), acidemia (from 7.45 ± 0.02 to 7.36 ± 0.02), and a 20% reduction in stroke volume. Mild hemorrhage and CO2 insufflation resulted in a similar degree of acidemia (7.35 ± 0.01), but moderate hemorrhage and CO2 insufflation led to more severe acidemia (7.26 ± 0.02). Fluid resuscitation failed to prevent this severe fall in pH (7.30 ± 0.03) for group 4. PaCO2 was not affected by hemorrhage, but CO2 pneumoperitoneum induced significant hypercapnia in all groups, ranging from 48 ± 1 mm Hg for euvolemic animals to 52 ± 1 mm Hg for moderate hemorrhage animals. Stroke volume declined as a function of blood loss, and it was further depressed by CO2 insufflation, to as low as 75% of baseline in mild hemorrhage and 55% of baseline in moderate hemorrhage. Both stroke volume and cardiac index initially responded to large-volume fluid replacement after moderate hemorrhage but quickly decreased to levels comparable to those of unresuscitated animals when CO2 pneumoperitoneum was created. Conclusions. Intraperitoneal insufflation with CO2 for diagnostic laparoscopy may be hazardous in acute hypovolemic trauma patients.

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