The effects of clozapine and risperidone on spatial working memory in schizophrenia

Susan R. McGurk, Cameron Carter, Robert Goldman, Michael F. Green, Stephen R. Marder, Haiyi Xie, Nina R. Schooler, John M. Kane

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Objective: The purpose of this investigation was to evaluate the effects of clozapine and risperidone on spatial working memory in patients with schizophrenia. Method: Spatial working memory performance was evaluated at baseline and after 17 and 29 weeks in 97 patients with schizophrenia participating in a multisite trial. Results: Compared with baseline performance while receiving conventional antipsychotic medication, risperidone improved, and clozapine worsened, spatial working memory performance. Conclusions: The differential effects of these medications on spatial working memory may be due to the anticholinergic effects of clozapine and prefrontal dopamine-enhancing effects of risperidone.

Original languageEnglish (US)
Pages (from-to)1013-1016
Number of pages4
JournalAmerican Journal of Psychiatry
Volume162
Issue number5
DOIs
StatePublished - May 2005

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    McGurk, S. R., Carter, C., Goldman, R., Green, M. F., Marder, S. R., Xie, H., Schooler, N. R., & Kane, J. M. (2005). The effects of clozapine and risperidone on spatial working memory in schizophrenia. American Journal of Psychiatry, 162(5), 1013-1016. https://doi.org/10.1176/appi.ajp.162.5.1013