The effects of antipsychotic medication on sequential inhibitory processes

Ruth Salo, Lynn C. Robertson, Thomas E Nordahl, Louis W. Kraft

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


The authors used a Stroop negative priming paradigm to examine the effects of antipsychotic medication on selective attentional processes. The performance of 14 patients with schizophrenia who were withdrawn from neuroleptic medication was compared with that of 10 medicated patients and 16 matched controls. Results demonstrated an increase in negative priming to normal levels with neurolepetic therapy. In contrast, within-trial interference and facilitation effects appeared to be less sensitive to medication therapy. The sustainment of inhibitory processes over time may differentiate the inhibitory mechanisms of the medication-withdrawn patients from both the medicated patients and the matched controls. The study of sequential inhibitory processes and their response to neuroleptic treatment could be important methods for understanding the temporal parameters associated with inhibition in schizophrenia.

Original languageEnglish (US)
Pages (from-to)639-643
Number of pages5
JournalJournal of Abnormal Psychology
Issue number4
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Psychology
  • Experimental and Cognitive Psychology
  • Psychology(all)


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