The effect of zinc deficiency on prostaglandin synthesis in rat testes

P. Chanmugam, C. Wheeler, D. H. Hwang

Research output: Contribution to journalArticle

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Abstract

The effect of zinc deficiency on prostaglandin synthesis in rat testes was determined by feeding three groups of rats egg white-based semipurified diets. One group (ZD) was fed a zinc-deficient diet and two control groups were pair-fed (PF) or fed ad libitum (AL) a zinc-sufficient diet. The concentration (nanograms/gram) of the prostacyclin metabolite, 6-keto-prostaglandin-F(1α) (6-keto-PGF(1α)), in the tunica of the homogenate was significantly lower in ZD than in PF and AL groups. However, there was no difference when 6-keto-PGF(1α) concentration was expressed as nanograms/milligrams of tunica protein. Tunica PGE2 concentrations (nanograms/gram) were not significantly altered by zinc deficiency. Concentrations of prostaglandins (PGs) in testis parenchyma were slighty higher in ZD probably as a result of increased levels of the precursor, arachidonic acid (AA). There was a highly significant correlation between PGE2 and AA in parenchyma phospholipids. PG synthesis was much greater in the tunica than in the parenchyma and prostacyclin appeared to be the major PG synthesized in both the tunica and parenchyma. It was concluded that PG synthesis is altered in the testes of zinc-deficient rats probably due to changes in concentrations of protein in the tunica and AA levels in parenchyma lipids.

Original languageEnglish (US)
Pages (from-to)2066-2072
Number of pages7
JournalJournal of Nutrition
Volume114
Issue number11
StatePublished - 1984
Externally publishedYes

Fingerprint

prostaglandins
Prostaglandins
Testis
Zinc
testes
zinc
Prostaglandins F
synthesis
Arachidonic Acid
rats
arachidonic acid
prostacyclin
Epoprostenol
Diet
Dinoprostone
Egg White
diet
egg albumen
Phospholipids
Proteins

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Chanmugam, P., Wheeler, C., & Hwang, D. H. (1984). The effect of zinc deficiency on prostaglandin synthesis in rat testes. Journal of Nutrition, 114(11), 2066-2072.

The effect of zinc deficiency on prostaglandin synthesis in rat testes. / Chanmugam, P.; Wheeler, C.; Hwang, D. H.

In: Journal of Nutrition, Vol. 114, No. 11, 1984, p. 2066-2072.

Research output: Contribution to journalArticle

Chanmugam, P, Wheeler, C & Hwang, DH 1984, 'The effect of zinc deficiency on prostaglandin synthesis in rat testes', Journal of Nutrition, vol. 114, no. 11, pp. 2066-2072.
Chanmugam P, Wheeler C, Hwang DH. The effect of zinc deficiency on prostaglandin synthesis in rat testes. Journal of Nutrition. 1984;114(11):2066-2072.
Chanmugam, P. ; Wheeler, C. ; Hwang, D. H. / The effect of zinc deficiency on prostaglandin synthesis in rat testes. In: Journal of Nutrition. 1984 ; Vol. 114, No. 11. pp. 2066-2072.
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