The effect of weight loss and dietary fatty acids on inflammation

Sridevi Devaraj, Siddika E Karakas, Ishwarlal Jialal

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Inflammation plays a pivotal role in all stages of atherosclerosis. Weight loss appears to be the best nonpharmacologic modality to reduce inflammation. Intervention trials convincingly demonstrate that weight loss reduces biomarkers of inflammation, such as C-reactive protein. Limited studies have shown that certain dietary fatty acids (ie, oleic acid and α-linolenic acid) reduce biomarkers of inflammation. Most of the studies with fish oil supplementation have shown null effects, and conflicting results have been reported with saturated and trans fatty acids. Much further research is needed to define the role of individual dietary factors on the biomarkers of inflammation and the mechanism of the anti-inflammatory effects of weight loss.

Original languageEnglish (US)
Pages (from-to)477-486
Number of pages10
JournalCurrent Atherosclerosis Reports
Volume8
Issue number6
DOIs
StatePublished - Nov 2006

Fingerprint

Weight Loss
Fatty Acids
Inflammation
Biomarkers
Trans Fatty Acids
alpha-Linolenic Acid
Fish Oils
Oleic Acid
C-Reactive Protein
Atherosclerosis
Anti-Inflammatory Agents
Research

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The effect of weight loss and dietary fatty acids on inflammation. / Devaraj, Sridevi; Karakas, Siddika E; Jialal, Ishwarlal.

In: Current Atherosclerosis Reports, Vol. 8, No. 6, 11.2006, p. 477-486.

Research output: Contribution to journalArticle

Devaraj, Sridevi ; Karakas, Siddika E ; Jialal, Ishwarlal. / The effect of weight loss and dietary fatty acids on inflammation. In: Current Atherosclerosis Reports. 2006 ; Vol. 8, No. 6. pp. 477-486.
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