The effect of vitamin E supplementation on LDL oxidation in dialysis patients

D. O'Byrne, K. Islam, B. Palmer, S. Devaraj, I. Jialal

Research output: Contribution to journalArticle

Abstract

Atherosclerotic cardiovascular disease is the leading cause of death in patients with end stage renal disease (ESRD) on dialysis. Dyslipidemia is a characteristic of most dialysis patients and may contribute to the high cardiovascular mortality. Oxidation of low density lipoprotein (LDL) may be the crucial step in the pathogenesis of atherosclerosis. Alpha-tocopherol (AT) is the major antioxidant in LDL and dietary supplementation has been shown to increase the oxidative resistence of LDL. The purpose of this study was to test the effect of AT supplementation on oxidative resistance of LDL in patients with chronic renal failure and healthy controls. 10 hemodialysis (HD), 10 peritoneal dialysis (PD), and 10 healthy controls (C) matched for age and gender were given 800 IU/day AT for 12 weeks. LDL was isolated by ultracentrifugation at baseline and after supplementation, and subjected to copper-catalyzed oxidation for 5 hours. Oxidation was measured by the formation of conjugated dienes (CD) and lipid peroxides (LP). Following AT supplementation, CD lag time increased significantly by 40% in the C group, 42% in the HD group, and by 57% in the PD group (p<0.005). Similarly, lipid peroxide lag phase was prolonged by 31%, 33%, and 47%, in C, HD, and PD, respectively (p<0.025). These results indicate that ESRD patients on dialysis respond favorably to AT supplementation.

Original languageEnglish (US)
JournalFASEB Journal
Volume12
Issue number5
StatePublished - Mar 20 1998
Externally publishedYes

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Dialysis
alpha-Tocopherol
low density lipoprotein
dialysis
Vitamin E
LDL Lipoproteins
vitamin E
alpha-tocopherol
oxidation
Peritoneal Dialysis
Oxidation
hemodialysis
Chronic Kidney Failure
Renal Dialysis
Lipid Peroxides
kidney diseases
peroxides
Ultracentrifugation
Dyslipidemias
Dietary Supplements

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

O'Byrne, D., Islam, K., Palmer, B., Devaraj, S., & Jialal, I. (1998). The effect of vitamin E supplementation on LDL oxidation in dialysis patients. FASEB Journal, 12(5).

The effect of vitamin E supplementation on LDL oxidation in dialysis patients. / O'Byrne, D.; Islam, K.; Palmer, B.; Devaraj, S.; Jialal, I.

In: FASEB Journal, Vol. 12, No. 5, 20.03.1998.

Research output: Contribution to journalArticle

O'Byrne, D, Islam, K, Palmer, B, Devaraj, S & Jialal, I 1998, 'The effect of vitamin E supplementation on LDL oxidation in dialysis patients', FASEB Journal, vol. 12, no. 5.
O'Byrne D, Islam K, Palmer B, Devaraj S, Jialal I. The effect of vitamin E supplementation on LDL oxidation in dialysis patients. FASEB Journal. 1998 Mar 20;12(5).
O'Byrne, D. ; Islam, K. ; Palmer, B. ; Devaraj, S. ; Jialal, I. / The effect of vitamin E supplementation on LDL oxidation in dialysis patients. In: FASEB Journal. 1998 ; Vol. 12, No. 5.
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