The effect of ventromedial hypothalamic lesions on adipose cell number in the rat

J. S. Stern, R. E. Keesey

Research output: Contribution to journalArticle

7 Scopus citations


The present experiment examined the effects of ventromedial hypothalamic (VMH) lesions upon adipocyte number of adult female rats. Female Sprague-Dawley rats lesioned at 10 weeks of age and killed at 50 weeks displayed a two-fold increase in body weight and a four-fold cell number increase in the parametrial, retroperitoneal and subcutaneous adipose depots. Though at variance with several earlier reports on VMH-lesioned rats, these results add to a growing body of evidence that factors leading to overnutrition and excessive weight gain can produce significant increases in fat cell number even in the adult.

Original languageEnglish (US)
Pages (from-to)295-301
Number of pages7
JournalNutrition Reports International
Issue number2
StatePublished - 1981


ASJC Scopus subject areas

  • Food Science
  • Biochemistry
  • Endocrinology
  • Medicine (miscellaneous)

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