The present experiment examined the effects of ventromedial hypothalamic (VMH) lesions upon adipocyte number of adult female rats. Female Sprague-Dawley rats lesioned at 10 weeks of age and killed at 50 weeks displayed a two-fold increase in body weight and a four-fold cell number increase in the parametrial, retroperitoneal and subcutaneous adipose depots. Though at variance with several earlier reports on VMH-lesioned rats, these results add to a growing body of evidence that factors leading to overnutrition and excessive weight gain can produce significant increases in fat cell number even in the adult.
|Original language||English (US)|
|Number of pages||7|
|Journal||Nutrition Reports International|
|State||Published - 1981|
ASJC Scopus subject areas
- Food Science
- Medicine (miscellaneous)