TY - JOUR
T1 - The effect of time since stroke, gender, age, and lesion size on thalamus volume in chronic stroke
T2 - a pilot study
AU - Krishnamurthy, Lisa C.
AU - Champion, Gabriell N.
AU - McGregor, Keith M.
AU - Krishnamurthy, Venkatagiri
AU - Turabi, Aaminah
AU - Roberts, Simone R.
AU - Nocera, Joe R.
AU - Borich, Michael R.
AU - Rodriguez, Amy D.
AU - Belagaje, Samir R.
AU - Harrington, Rachael M.
AU - Harris-Love, Michelle L.
AU - Harnish, Stacy M.
AU - Drucker, Jonathan H.
AU - Benjamin, Michelle
AU - Meadows, M. Lawson
AU - Seeds, Lauren
AU - Zlatar, Zvinka Z.
AU - Sudhyadhom, Atchar
AU - Butler, Andrew J.
AU - Garcia, Amanda
AU - Patten, Carolynn
AU - Trinastic, Jonathan
AU - Kautz, Steven A.
AU - Gregory, Chris
AU - Crosson, Bruce A.
N1 - Funding Information:
This work was supported by the Veterans Affairs Rehabilitation Research & Development Service (USA) Grant IK1 RX002629.
PY - 2020/12
Y1 - 2020/12
N2 - Recent stroke studies have shown that the ipsi-lesional thalamus longitudinally and significantly decreases after stroke in the acute and subacute stages. However, additional considerations in the chronic stages of stroke require exploration including time since stroke, gender, intracortical volume, aging, and lesion volume to better characterize thalamic differences after cortical infarct. This cross-sectional retrospective study quantified the ipsilesional and contralesional thalamus volume from 69 chronic stroke subjects’ anatomical MRI data (age 35–92) and related the thalamus volume to time since stroke, gender, intracortical volume, age, and lesion volume. The ipsi-lesional thalamus volume was significantly smaller than the contra-lesional thalamus volume (t(68) = 13.89, p < 0.0001). In the ipsilesional thalamus, significant effect for intracortical volume (t(68) = 2.76, p = 0.008), age (t(68) = 2.47, p = 0.02), lesion volume (t(68) = − 3.54, p = 0.0008), and age*time since stroke (t(68) = 2.46, p = 0.02) were identified. In the contralesional thalamus, significant effect for intracortical volume (t(68) = 3.2, p = 0.002) and age (t = − 3.17, p = 0.002) were identified. Clinical factors age and intracortical volume influence both ipsi- and contralesional thalamus volume and lesion volume influences the ipsilesional thalamus. Due to the cross-sectional nature of this study, additional research is warranted to understand differences in the neural circuitry and subsequent influence on volumetrics after stroke.
AB - Recent stroke studies have shown that the ipsi-lesional thalamus longitudinally and significantly decreases after stroke in the acute and subacute stages. However, additional considerations in the chronic stages of stroke require exploration including time since stroke, gender, intracortical volume, aging, and lesion volume to better characterize thalamic differences after cortical infarct. This cross-sectional retrospective study quantified the ipsilesional and contralesional thalamus volume from 69 chronic stroke subjects’ anatomical MRI data (age 35–92) and related the thalamus volume to time since stroke, gender, intracortical volume, age, and lesion volume. The ipsi-lesional thalamus volume was significantly smaller than the contra-lesional thalamus volume (t(68) = 13.89, p < 0.0001). In the ipsilesional thalamus, significant effect for intracortical volume (t(68) = 2.76, p = 0.008), age (t(68) = 2.47, p = 0.02), lesion volume (t(68) = − 3.54, p = 0.0008), and age*time since stroke (t(68) = 2.46, p = 0.02) were identified. In the contralesional thalamus, significant effect for intracortical volume (t(68) = 3.2, p = 0.002) and age (t = − 3.17, p = 0.002) were identified. Clinical factors age and intracortical volume influence both ipsi- and contralesional thalamus volume and lesion volume influences the ipsilesional thalamus. Due to the cross-sectional nature of this study, additional research is warranted to understand differences in the neural circuitry and subsequent influence on volumetrics after stroke.
UR - http://www.scopus.com/inward/record.url?scp=85096608000&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85096608000&partnerID=8YFLogxK
U2 - 10.1038/s41598-020-76382-x
DO - 10.1038/s41598-020-76382-x
M3 - Article
C2 - 33235210
AN - SCOPUS:85096608000
VL - 10
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 20488
ER -