The effect of thiamin tetrahydrofurfuryl disulfide on behavior of juvenile DBA/2J mice

Judith I. Hills, Mari S. Golub, Lucien Bettendorff, Carl L Keen

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Due to genetic defects or illness some individuals require higher amounts of thiamin than are typically provided by the diet. Lipid-soluble thiamin precursors can achieve high blood levels of thiamin and result in increased concentrations in the central nervous system. High intakes of thiamin have been reported as beneficial in children with autism and attention deficit/hyperactivity disorder. The current study examined the effect of thiamin tetrahydrofurfuryl disulfide (TTFD), a lipophilic precursor, on behavior in the juvenile male DBA/2J mouse. Mice given by oral gavage deionized water or deionized water providing 100. mg or 340. mg TTFD/kg body weight daily for 17. d, starting at postnatal day 18, were tested for effects on operant learning, social interaction, general activity level, and prepulse inhibition of acoustic startle, as well as effects on growth and select organ weights. Results indicate lower activity and altered social interaction at both treatment levels and decreased acoustic startle at the 100. mg/kg level. Compared to controls, percent weight gain was lower in the TTFD-treatment groups, but percent body length increase was not affected by TTFD treatment. TTFD treatment did not influence percent organ weights as percentage of body weights. TTFD treatment resulted in increased whole brain thiamin concentrations. These results support the concept that lipophilic thiamin precursors provided during early development can affect a number of behavioral parameters. In clinical trials with children with behavior disorders, attention should be given to preventing possible adverse gastrointestinal irritant effects associated with TTFD therapy.

Original languageEnglish (US)
Pages (from-to)242-252
Number of pages11
JournalNeurotoxicology and Teratology
Issue number2
StatePublished - Mar 2012


  • Acoustic startle prepulse inhibition
  • Activity
  • Behavior
  • Learning
  • Social
  • Thiamin

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience
  • Toxicology


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