Abstract
The efficacy of various doses of RU 486 in terminating pregnancy before and after the luteal-placental shift (LPS) in the long-tailed macaque (Macaca fascicularis) was assessed through sonographic examination and measurements of steroid hormones and their metabolites. Intramuscular injection of 1.0, 2.5,12.5, or 25.0 mg/kg was administered either from gestational day (GD) 15-18 (Group 1; N = 11) or GD 23-26 (Group 2; N = 9). The timing of treatment was determined by the detection of the preovulatory estrogen peak via daily urinary estrone conjugate (E1C) measurements. In Group 1, a 90.9% pregnancy loss was observed ( 10 11); seven animals aborted during GD 15-20, two animals indicated early embryonic death with retained gestational sacs, one animal aborted on GD 56, and one pregnancy was maintained. In Group 2, an 88.9% pregnancy loss was observed ( 8 9); eight animals aborted between GD 26-29, and one pregnancy was unaffected. Hormone profiles appeared to fall secondarily to the loss of trophoblast function. These results indicate: (a) RU 486 was more effective after the LPS; and (b) the primary effect of RU 486 appeared to be at the level of the products of conception.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 201-211 |
| Number of pages | 11 |
| Journal | Contraception |
| Volume | 40 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1989 |
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ASJC Scopus subject areas
- Medicine(all)
- Obstetrics and Gynecology
Cite this
The effect of the anti-progestin ru 486 on early pregnancy in the long-tailed macaque (Macaca fascicularis). / Owiti, George E O; Tarantal, Alice F; Lasley, Bill L.; Hendrickx, Andrew G.
In: Contraception, Vol. 40, No. 2, 1989, p. 201-211.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of the anti-progestin ru 486 on early pregnancy in the long-tailed macaque (Macaca fascicularis)
AU - Owiti, George E O
AU - Tarantal, Alice F
AU - Lasley, Bill L.
AU - Hendrickx, Andrew G
PY - 1989
Y1 - 1989
N2 - The efficacy of various doses of RU 486 in terminating pregnancy before and after the luteal-placental shift (LPS) in the long-tailed macaque (Macaca fascicularis) was assessed through sonographic examination and measurements of steroid hormones and their metabolites. Intramuscular injection of 1.0, 2.5,12.5, or 25.0 mg/kg was administered either from gestational day (GD) 15-18 (Group 1; N = 11) or GD 23-26 (Group 2; N = 9). The timing of treatment was determined by the detection of the preovulatory estrogen peak via daily urinary estrone conjugate (E1C) measurements. In Group 1, a 90.9% pregnancy loss was observed ( 10 11); seven animals aborted during GD 15-20, two animals indicated early embryonic death with retained gestational sacs, one animal aborted on GD 56, and one pregnancy was maintained. In Group 2, an 88.9% pregnancy loss was observed ( 8 9); eight animals aborted between GD 26-29, and one pregnancy was unaffected. Hormone profiles appeared to fall secondarily to the loss of trophoblast function. These results indicate: (a) RU 486 was more effective after the LPS; and (b) the primary effect of RU 486 appeared to be at the level of the products of conception.
AB - The efficacy of various doses of RU 486 in terminating pregnancy before and after the luteal-placental shift (LPS) in the long-tailed macaque (Macaca fascicularis) was assessed through sonographic examination and measurements of steroid hormones and their metabolites. Intramuscular injection of 1.0, 2.5,12.5, or 25.0 mg/kg was administered either from gestational day (GD) 15-18 (Group 1; N = 11) or GD 23-26 (Group 2; N = 9). The timing of treatment was determined by the detection of the preovulatory estrogen peak via daily urinary estrone conjugate (E1C) measurements. In Group 1, a 90.9% pregnancy loss was observed ( 10 11); seven animals aborted during GD 15-20, two animals indicated early embryonic death with retained gestational sacs, one animal aborted on GD 56, and one pregnancy was maintained. In Group 2, an 88.9% pregnancy loss was observed ( 8 9); eight animals aborted between GD 26-29, and one pregnancy was unaffected. Hormone profiles appeared to fall secondarily to the loss of trophoblast function. These results indicate: (a) RU 486 was more effective after the LPS; and (b) the primary effect of RU 486 appeared to be at the level of the products of conception.
UR - http://www.scopus.com/inward/record.url?scp=0024348012&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024348012&partnerID=8YFLogxK
U2 - 10.1016/0010-7824(89)90007-3
DO - 10.1016/0010-7824(89)90007-3
M3 - Article
C2 - 2758841
AN - SCOPUS:0024348012
VL - 40
SP - 201
EP - 211
JO - Contraception
JF - Contraception
SN - 0010-7824
IS - 2
ER -