The effect of structurally divergent herbicides on mouse liver xenobiotic-metabolizing enzymes (P-450-dependent mono-oxygenases, epoxide hydrolases and glutathione S-transferases) and carnitine acetyltransferase

David E. Moody, Bruce A. Narloch, Lee R. Shull, Bruce D. Hammock

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Male mice were treated with structurally diverse herbicides to study their effect on liver xenobiotic-metabolizing enzymes. Chlorfiurecol, trifluralin, alachlor, propham, MCPP and 2,4-DP caused increases in phase I (cytochrome P-450, ethoxycoumarin O-deethylase, and/or aminopyrine N-demethylase) and phase II (microsomal epoxide hydrolase and cytosolic glutathione S-transferase) activities. MCPP and 2,4-DP also increased cytosolic epoxide hydrolase and carnitine acetyltransferase activities suggestive of peroxisome proliferation. Benthiocarb and molinate increased only some phase II enzyme activities. Dicamba, at the dose employed, caused mortality and decreases in some of the enzymes monitored. Most of the herbicides tested induced xenobiotic-metabolizing enzyme activities, the pattern of induction being dependent on herbicide structure.

Original languageEnglish (US)
Pages (from-to)175-185
Number of pages11
JournalToxicology Letters
Volume59
Issue number1-3
DOIs
StatePublished - 1991

Keywords

  • Carnitine acetyltransferase
  • Cytochrome P-450
  • Epoxide hydrolase
  • Glutathione S-transferase
  • Herbicides
  • Peroxisome proliferation

ASJC Scopus subject areas

  • Toxicology

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