The rate of rise of the alveolar : inspired halothane concentration (F(A)/F(I)) ratio was measured in dogs breathing spontaneously. These rates were measured at inspired concentrations of 0.3, 1.5, and 4%. Initially, F(A)/F(I) rose at similar rates for all 3 concentrations, but at 4%, the plateau attained was lower as a result of respiratory depression. In a 2nd group of dogs, F(A)/F(I) was measured for inspired concentrations of 0.3, 1.5, 4, and 6% during controlled ventilation. F(A)/F(I) rose at similar rates at the lower 2 concentrations but at progressively more rapid rates at inspired concentrations of 4 and 6%, presumably as a result of circulatory depression.
|Original language||English (US)|
|Number of pages||3|
|Journal||Anesthesia and Analgesia|
|State||Published - Jan 1 1977|
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine