The effect of spontaneous versus controlled ventilation on the rate of rise of alveolar halothane concentration in dogs

R. T. Gibbons; Eugene Steffey; E. I. Eger

The effect of spontaneous versus controlled ventilation on the rate of rise of alveolar halothane concentration in dogs

R. T. Gibbons, Eugene Steffey, E. I. Eger

Research output: Contribution to journal › Article › peer-review

Abstract

The rate of rise of the alveolar : inspired halothane concentration (F(A)/F(I)) ratio was measured in dogs breathing spontaneously. These rates were measured at inspired concentrations of 0.3, 1.5, and 4%. Initially, F(A)/F(I) rose at similar rates for all 3 concentrations, but at 4%, the plateau attained was lower as a result of respiratory depression. In a 2nd group of dogs, F(A)/F(I) was measured for inspired concentrations of 0.3, 1.5, 4, and 6% during controlled ventilation. F(A)/F(I) rose at similar rates at the lower 2 concentrations but at progressively more rapid rates at inspired concentrations of 4 and 6%, presumably as a result of circulatory depression.

Original language	English (US)
Pages (from-to)	32-34
Number of pages	3
Journal	Anesthesia and Analgesia
Volume	56
Issue number	1
State	Published - Jan 1 1977
Externally published	Yes

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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abstract = "The rate of rise of the alveolar : inspired halothane concentration (F(A)/F(I)) ratio was measured in dogs breathing spontaneously. These rates were measured at inspired concentrations of 0.3, 1.5, and 4%. Initially, F(A)/F(I) rose at similar rates for all 3 concentrations, but at 4%, the plateau attained was lower as a result of respiratory depression. In a 2nd group of dogs, F(A)/F(I) was measured for inspired concentrations of 0.3, 1.5, 4, and 6% during controlled ventilation. F(A)/F(I) rose at similar rates at the lower 2 concentrations but at progressively more rapid rates at inspired concentrations of 4 and 6%, presumably as a result of circulatory depression.",

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