The effect of size on the acoustic response of polymer-shelled contrast agents

Susannah H. Bloch, Robert E. Short, Katherine W. Ferrara, Erik R Wisner

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

In this technical note, we study three polymer-shelled microbubble contrast agents manufactured by POINT Biomedical Corporation that have identical shell composition and mean volumetric diameters of 0.74 μm, 0.91 μm and 1.33 μm. We investigate the effect of agent size on the amplitude, frequency and probability of acoustic echoes received in response to five-cycle, 2.25-MHz pulses of varying pressure. We find that the amplitude and frequency response from the three agents is not significantly different. However, significant differences among the agents do exist in the probability of response to acoustic interrogation: at a pressure of 1.06 MPa, an echo from the 1.33 μm agent is 5 times as likely as an echo from the 0.91 μm agent and 18 times as likely as an echo from the 0.74 μm agent. We hypothesize that there exists an effective pressure-dependent threshold diameter above which single polymer-shelled agents respond to acoustic interrogation.

Original languageEnglish (US)
Pages (from-to)439-444
Number of pages6
JournalUltrasound in Medicine and Biology
Volume31
Issue number3
DOIs
StatePublished - Mar 2005

Keywords

  • Acoustic response
  • Contrast agent
  • Microbubbles
  • Polymer-shelled
  • Submicron
  • Ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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