The Effect of Short, High Intensity Magnetic Field Pulses on the Healing of Skin Wounds in Rats

Joshua Milgram, Ron Shahar, Tal Levin-Harrus, Philip H Kass

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The object of this study was to examine the effect of high intensity, short duration pulsed electromagnetic fields (PEMF) on the healing of full thickness skin wounds in rats. Full thickness skin wounds were surgically created in two groups of Sprague-Dawley male rats. The rats were randomly divided into two groups, each containing 20 rats. Animals in the treatment group received treatments with the PEMF device on day 0, 3, 7, 9, 12, 14, 17, and 22, while the rats in the control group were subjected to the same procedure, but with the PEMF device not activated. Photographs of the surgically created wounds were obtained on day 0, 3, 7, 9, 12, 14, 17, and 22. Wound contraction (WC), wound epithelialization (WE), non-healed wound, and contraction-epithelialization (CE) ratio were calculated for each wound. No significant difference was found between the two groups for the parameters of WC, WE, non-healed wound, and CE ratio. A significant group x time interaction was found for WE and CE ratio. This type of PEMF did not have a significantly beneficial effect on wound healing. Wounds in the PEMF treated group were relatively less contracted and showed a compensatory increase in epithelialization in the early stages of wound repair.

Original languageEnglish (US)
Pages (from-to)271-277
Number of pages7
JournalBioelectromagnetics
Volume25
Issue number4
DOIs
StatePublished - May 2004

Fingerprint

Magnetic Fields
magnetic fields
skin (animal)
animal injuries
Wound Healing
Re-Epithelialization
Electromagnetic Fields
Skin
rats
Wounds and Injuries
Equipment and Supplies
Sprague Dawley Rats
tissue repair
Control Groups
photographs
electromagnetic field

Keywords

  • Contraction
  • Epithelialization
  • PEMF
  • Rats
  • Skin wounds

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biophysics

Cite this

The Effect of Short, High Intensity Magnetic Field Pulses on the Healing of Skin Wounds in Rats. / Milgram, Joshua; Shahar, Ron; Levin-Harrus, Tal; Kass, Philip H.

In: Bioelectromagnetics, Vol. 25, No. 4, 05.2004, p. 271-277.

Research output: Contribution to journalArticle

Milgram, Joshua ; Shahar, Ron ; Levin-Harrus, Tal ; Kass, Philip H. / The Effect of Short, High Intensity Magnetic Field Pulses on the Healing of Skin Wounds in Rats. In: Bioelectromagnetics. 2004 ; Vol. 25, No. 4. pp. 271-277.
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