The effect of seven vasopressors on halothane mac in dogs

Eugene Steffey, E. I. Eger

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Summary: We evaluated the effects of ephedrine, mephentermine, metaraminol, phenylephrine, methoxamine, noradrenaline and adrenaline on halothane anaesthetic requirement (MAC) in dogs. MAC increased significantly only during ephedrine infusion (50%) although significance was approached with mephentermine (21%). Phenylephrine, metaraminol, methoxamine, noradrenaline and adrenaline did not change MAC. Arterial pressure was increased 50-100% with all agents. Our results support the hypothesis that anaesthetic requirement may be related, in part, to release of brain noradrenaline.

Original languageEnglish (US)
Pages (from-to)435-438
Number of pages4
JournalBritish Journal of Anaesthesia
Issue number4
StatePublished - Apr 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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