The effect of seven vasopressors on halothane mac in dogs

Eugene Steffey, E. I. Eger

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Summary: We evaluated the effects of ephedrine, mephentermine, metaraminol, phenylephrine, methoxamine, noradrenaline and adrenaline on halothane anaesthetic requirement (MAC) in dogs. MAC increased significantly only during ephedrine infusion (50%) although significance was approached with mephentermine (21%). Phenylephrine, metaraminol, methoxamine, noradrenaline and adrenaline did not change MAC. Arterial pressure was increased 50-100% with all agents. Our results support the hypothesis that anaesthetic requirement may be related, in part, to release of brain noradrenaline.

Original languageEnglish (US)
Pages (from-to)435-438
Number of pages4
JournalBritish Journal of Anaesthesia
Volume47
Issue number4
DOIs
StatePublished - Apr 1 1975
Externally publishedYes

Fingerprint

Mephentermine
Halothane
Metaraminol
Methoxamine
Ephedrine
Norepinephrine
Phenylephrine
Dogs
Epinephrine
Anesthetics
Arterial Pressure
Brain

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

The effect of seven vasopressors on halothane mac in dogs. / Steffey, Eugene; Eger, E. I.

In: British Journal of Anaesthesia, Vol. 47, No. 4, 01.04.1975, p. 435-438.

Research output: Contribution to journalArticle

@article{1d2e84ab64014c07984aba45662b2d6e,
title = "The effect of seven vasopressors on halothane mac in dogs",
abstract = "Summary: We evaluated the effects of ephedrine, mephentermine, metaraminol, phenylephrine, methoxamine, noradrenaline and adrenaline on halothane anaesthetic requirement (MAC) in dogs. MAC increased significantly only during ephedrine infusion (50{\%}) although significance was approached with mephentermine (21{\%}). Phenylephrine, metaraminol, methoxamine, noradrenaline and adrenaline did not change MAC. Arterial pressure was increased 50-100{\%} with all agents. Our results support the hypothesis that anaesthetic requirement may be related, in part, to release of brain noradrenaline.",
author = "Eugene Steffey and Eger, {E. I.}",
year = "1975",
month = "4",
day = "1",
doi = "10.1093/bja/47.4.435",
language = "English (US)",
volume = "47",
pages = "435--438",
journal = "British Journal of Anaesthesia",
issn = "0007-0912",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - The effect of seven vasopressors on halothane mac in dogs

AU - Steffey, Eugene

AU - Eger, E. I.

PY - 1975/4/1

Y1 - 1975/4/1

N2 - Summary: We evaluated the effects of ephedrine, mephentermine, metaraminol, phenylephrine, methoxamine, noradrenaline and adrenaline on halothane anaesthetic requirement (MAC) in dogs. MAC increased significantly only during ephedrine infusion (50%) although significance was approached with mephentermine (21%). Phenylephrine, metaraminol, methoxamine, noradrenaline and adrenaline did not change MAC. Arterial pressure was increased 50-100% with all agents. Our results support the hypothesis that anaesthetic requirement may be related, in part, to release of brain noradrenaline.

AB - Summary: We evaluated the effects of ephedrine, mephentermine, metaraminol, phenylephrine, methoxamine, noradrenaline and adrenaline on halothane anaesthetic requirement (MAC) in dogs. MAC increased significantly only during ephedrine infusion (50%) although significance was approached with mephentermine (21%). Phenylephrine, metaraminol, methoxamine, noradrenaline and adrenaline did not change MAC. Arterial pressure was increased 50-100% with all agents. Our results support the hypothesis that anaesthetic requirement may be related, in part, to release of brain noradrenaline.

UR - http://www.scopus.com/inward/record.url?scp=0016789744&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016789744&partnerID=8YFLogxK

U2 - 10.1093/bja/47.4.435

DO - 10.1093/bja/47.4.435

M3 - Article

C2 - 237518

AN - SCOPUS:0016789744

VL - 47

SP - 435

EP - 438

JO - British Journal of Anaesthesia

JF - British Journal of Anaesthesia

SN - 0007-0912

IS - 4

ER -