The effect of preoperative apolipoprotein a-I on the prognosis of surgical renal cell carcinoma a retrospective large sample study

Shengjie Guo, Xiaobo He, Qian Chen, Guangwei Yang, Kai Yao, Pei Dong, Yunlin Ye, Dong Chen, Zhiling Zhang, Zike Qin, Zhuowei Liu, Zaishang Li, Yunfei Xue, Meng Zhang, Ruiwu Liu, Fangjian Zhou, Hui Han

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The prognostic value of serum lipid-profile in renal cell cancer (RCC) remains unknown. The purpose of the study is to explore the association between the serum lipid-profile and RCC patients. The levels of preoperative serum lipid-profile (including cholesterol, triglycerides, high-density lipoprotein-cholesterol [HDL-C], lowdensity lipoprotein-cholesterol [LDL-C], apolipoprotein A-I [ApoAI], and apolipoprotein B [ApoB]) were retrospectively performed in 786 patients with RCC. The cutoff values of the lipids were determined by the receiver-operating characteristic (ROC) curve analysis. Univariate and multivariate Cox regression analyses were performed to investigate the prognostic value of serum lipids in RCC. Combined ROC analysis and univariate and multivariate Cox regression analyses, for overall survival (OS), revealed patients with low ApoA-I (<1.04) had significantly lower OS than the high ApoA-I (≥1.04) group (multivariate Cox regression analyses, hazard ratio [HR], 0.57; P=0.003). Not only in the whole RCC cohort but also in the subgroups stratified according to the pT1-2 (P=0.002), pN0 (P<0.001), and pM0 (P=0.001) status, respectively. Moreover, in the 755 patients with nonmetastasis, the low ApoA-I group was also associated with shortened disease-free survival (DFS) time compared to the high ApoA-I group (multivariate Cox regression analyses, HR, 0.65; P=0.033). However, the other lipids were not independent prognostic factors for surgical RCC. An elevated level of preoperative ApoA-I was demonstrated to be related with better survival in patients with surgical RCC. Measuring the preoperative ApoA-I might be a simple way for finding the poor prognostic patients who should enrolled in further clinical trials and management.

Original languageEnglish (US)
Article numbere3147
JournalMedicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries
Volume95
Issue number12
DOIs
StatePublished - 2016

Fingerprint

Apolipoproteins
Apolipoprotein A-I
Renal Cell Carcinoma
Lipids
Regression Analysis
Serum
ROC Curve
Survival
Apolipoproteins B
HDL Cholesterol
Disease-Free Survival
Triglycerides
Multivariate Analysis
Cholesterol
Clinical Trials

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The effect of preoperative apolipoprotein a-I on the prognosis of surgical renal cell carcinoma a retrospective large sample study. / Guo, Shengjie; He, Xiaobo; Chen, Qian; Yang, Guangwei; Yao, Kai; Dong, Pei; Ye, Yunlin; Chen, Dong; Zhang, Zhiling; Qin, Zike; Liu, Zhuowei; Li, Zaishang; Xue, Yunfei; Zhang, Meng; Liu, Ruiwu; Zhou, Fangjian; Han, Hui.

In: Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries, Vol. 95, No. 12, e3147, 2016.

Research output: Contribution to journalArticle

Guo, Shengjie ; He, Xiaobo ; Chen, Qian ; Yang, Guangwei ; Yao, Kai ; Dong, Pei ; Ye, Yunlin ; Chen, Dong ; Zhang, Zhiling ; Qin, Zike ; Liu, Zhuowei ; Li, Zaishang ; Xue, Yunfei ; Zhang, Meng ; Liu, Ruiwu ; Zhou, Fangjian ; Han, Hui. / The effect of preoperative apolipoprotein a-I on the prognosis of surgical renal cell carcinoma a retrospective large sample study. In: Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries. 2016 ; Vol. 95, No. 12.
@article{795880db4be84944bfa97a03b3efaa22,
title = "The effect of preoperative apolipoprotein a-I on the prognosis of surgical renal cell carcinoma a retrospective large sample study",
abstract = "The prognostic value of serum lipid-profile in renal cell cancer (RCC) remains unknown. The purpose of the study is to explore the association between the serum lipid-profile and RCC patients. The levels of preoperative serum lipid-profile (including cholesterol, triglycerides, high-density lipoprotein-cholesterol [HDL-C], lowdensity lipoprotein-cholesterol [LDL-C], apolipoprotein A-I [ApoAI], and apolipoprotein B [ApoB]) were retrospectively performed in 786 patients with RCC. The cutoff values of the lipids were determined by the receiver-operating characteristic (ROC) curve analysis. Univariate and multivariate Cox regression analyses were performed to investigate the prognostic value of serum lipids in RCC. Combined ROC analysis and univariate and multivariate Cox regression analyses, for overall survival (OS), revealed patients with low ApoA-I (<1.04) had significantly lower OS than the high ApoA-I (≥1.04) group (multivariate Cox regression analyses, hazard ratio [HR], 0.57; P=0.003). Not only in the whole RCC cohort but also in the subgroups stratified according to the pT1-2 (P=0.002), pN0 (P<0.001), and pM0 (P=0.001) status, respectively. Moreover, in the 755 patients with nonmetastasis, the low ApoA-I group was also associated with shortened disease-free survival (DFS) time compared to the high ApoA-I group (multivariate Cox regression analyses, HR, 0.65; P=0.033). However, the other lipids were not independent prognostic factors for surgical RCC. An elevated level of preoperative ApoA-I was demonstrated to be related with better survival in patients with surgical RCC. Measuring the preoperative ApoA-I might be a simple way for finding the poor prognostic patients who should enrolled in further clinical trials and management.",
author = "Shengjie Guo and Xiaobo He and Qian Chen and Guangwei Yang and Kai Yao and Pei Dong and Yunlin Ye and Dong Chen and Zhiling Zhang and Zike Qin and Zhuowei Liu and Zaishang Li and Yunfei Xue and Meng Zhang and Ruiwu Liu and Fangjian Zhou and Hui Han",
year = "2016",
doi = "10.1097/MD.0000000000003147",
language = "English (US)",
volume = "95",
journal = "Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries",
issn = "0025-7974",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

TY - JOUR

T1 - The effect of preoperative apolipoprotein a-I on the prognosis of surgical renal cell carcinoma a retrospective large sample study

AU - Guo, Shengjie

AU - He, Xiaobo

AU - Chen, Qian

AU - Yang, Guangwei

AU - Yao, Kai

AU - Dong, Pei

AU - Ye, Yunlin

AU - Chen, Dong

AU - Zhang, Zhiling

AU - Qin, Zike

AU - Liu, Zhuowei

AU - Li, Zaishang

AU - Xue, Yunfei

AU - Zhang, Meng

AU - Liu, Ruiwu

AU - Zhou, Fangjian

AU - Han, Hui

PY - 2016

Y1 - 2016

N2 - The prognostic value of serum lipid-profile in renal cell cancer (RCC) remains unknown. The purpose of the study is to explore the association between the serum lipid-profile and RCC patients. The levels of preoperative serum lipid-profile (including cholesterol, triglycerides, high-density lipoprotein-cholesterol [HDL-C], lowdensity lipoprotein-cholesterol [LDL-C], apolipoprotein A-I [ApoAI], and apolipoprotein B [ApoB]) were retrospectively performed in 786 patients with RCC. The cutoff values of the lipids were determined by the receiver-operating characteristic (ROC) curve analysis. Univariate and multivariate Cox regression analyses were performed to investigate the prognostic value of serum lipids in RCC. Combined ROC analysis and univariate and multivariate Cox regression analyses, for overall survival (OS), revealed patients with low ApoA-I (<1.04) had significantly lower OS than the high ApoA-I (≥1.04) group (multivariate Cox regression analyses, hazard ratio [HR], 0.57; P=0.003). Not only in the whole RCC cohort but also in the subgroups stratified according to the pT1-2 (P=0.002), pN0 (P<0.001), and pM0 (P=0.001) status, respectively. Moreover, in the 755 patients with nonmetastasis, the low ApoA-I group was also associated with shortened disease-free survival (DFS) time compared to the high ApoA-I group (multivariate Cox regression analyses, HR, 0.65; P=0.033). However, the other lipids were not independent prognostic factors for surgical RCC. An elevated level of preoperative ApoA-I was demonstrated to be related with better survival in patients with surgical RCC. Measuring the preoperative ApoA-I might be a simple way for finding the poor prognostic patients who should enrolled in further clinical trials and management.

AB - The prognostic value of serum lipid-profile in renal cell cancer (RCC) remains unknown. The purpose of the study is to explore the association between the serum lipid-profile and RCC patients. The levels of preoperative serum lipid-profile (including cholesterol, triglycerides, high-density lipoprotein-cholesterol [HDL-C], lowdensity lipoprotein-cholesterol [LDL-C], apolipoprotein A-I [ApoAI], and apolipoprotein B [ApoB]) were retrospectively performed in 786 patients with RCC. The cutoff values of the lipids were determined by the receiver-operating characteristic (ROC) curve analysis. Univariate and multivariate Cox regression analyses were performed to investigate the prognostic value of serum lipids in RCC. Combined ROC analysis and univariate and multivariate Cox regression analyses, for overall survival (OS), revealed patients with low ApoA-I (<1.04) had significantly lower OS than the high ApoA-I (≥1.04) group (multivariate Cox regression analyses, hazard ratio [HR], 0.57; P=0.003). Not only in the whole RCC cohort but also in the subgroups stratified according to the pT1-2 (P=0.002), pN0 (P<0.001), and pM0 (P=0.001) status, respectively. Moreover, in the 755 patients with nonmetastasis, the low ApoA-I group was also associated with shortened disease-free survival (DFS) time compared to the high ApoA-I group (multivariate Cox regression analyses, HR, 0.65; P=0.033). However, the other lipids were not independent prognostic factors for surgical RCC. An elevated level of preoperative ApoA-I was demonstrated to be related with better survival in patients with surgical RCC. Measuring the preoperative ApoA-I might be a simple way for finding the poor prognostic patients who should enrolled in further clinical trials and management.

UR - http://www.scopus.com/inward/record.url?scp=84962195221&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962195221&partnerID=8YFLogxK

U2 - 10.1097/MD.0000000000003147

DO - 10.1097/MD.0000000000003147

M3 - Article

C2 - 27015197

AN - SCOPUS:84962195221

VL - 95

JO - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries

JF - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries

SN - 0025-7974

IS - 12

M1 - e3147

ER -