The effect of MSH on thymidine incorporation by keratinocytes in the epidermal melanin unit

Kent L Erickson, F. Hu, L. Giacometti

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Abstract

Epidermal melanocytes were observed in the black but not in the white skin of black and white spotted guinea pigs. In experiments designed to determine whether melanocyte stimulating hormone (MSH) affects the incorporation of thymidine by keratinocyte nuclei of the epidermal melanin unit, the labeling index was the same in all skin before MSH administration. After MSH injections, the level of [3H]thymidine incorporation in keratinocytes increased significantly in black skin but not in white. The authors suggest that through the mediation of melanocytes MSH indirectly affects keratinocytes in the epidermal melanin unit.

Original languageEnglish (US)
Pages (from-to)367-370
Number of pages4
JournalJournal of Investigative Dermatology
Volume66
Issue number6
StatePublished - 1976
Externally publishedYes

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ASJC Scopus subject areas

  • Dermatology

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