The effect of isoflurane and halothane on electroencephalographic activation elicited by repetitive noxious c-fiber stimulation

Linda S Barter, Carmen L. Dominguez, Earl Carstens, Joseph F. Antognini

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Windup is the progressive increase in neuronal response to a repetitive noxious stimulus. This response is most often observed in the spinal cord, but it is unclear how this response is manifested in supraspinal structures. We investigated the effects of isoflurane and halothane on electroencephalographic responses to repetitive noxious electrical stimuli (20 pulses at 0.1, 1 and 3 Hz) applied to the tail in rats. Halothane and isoflurane concentrations were adjusted to 0.8 and 1.2 minimum alveolar concentration (MAC), where MAC is the concentration needed to prevent gross and purposeful movement in 50% of animals. At 0.8 MAC halothane, the 3 Hz stimulus caused electroencephalographic (EEG) activation primarily by increasing the median edge frequency (MEF), while at 1.2 MAC halothane the spectral edge frequency (SEF) was increased by the 1 and 3 Hz stimuli, and the MEF was increased by the 3 Hz stimuli. At 0.8 MAC isoflurane, the 1 and 3 Hz stimuli evoked EEG activation by increasing the MEF and SEF, while at 1.2 MAC only the MEF was increased by the 1 Hz stimulus. No EEG activation occurred with the 0.1 Hz repetitive stimulus with either isoflurane or halothane. These data suggest that repetitive electrical stimulation normally associated with windup in spinal neurons can evoke EEG activation.

Original languageEnglish (US)
Pages (from-to)242-247
Number of pages6
JournalNeuroscience Letters
Volume382
Issue number3
DOIs
StatePublished - Jul 15 2005

Fingerprint

Isoflurane
Halothane
Electric Stimulation
Tail
Spinal Cord
Neurons

Keywords

  • Electroencephalography
  • Halothane
  • Isoflurane
  • Windup

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The effect of isoflurane and halothane on electroencephalographic activation elicited by repetitive noxious c-fiber stimulation. / Barter, Linda S; Dominguez, Carmen L.; Carstens, Earl; Antognini, Joseph F.

In: Neuroscience Letters, Vol. 382, No. 3, 15.07.2005, p. 242-247.

Research output: Contribution to journalArticle

Barter, Linda S ; Dominguez, Carmen L. ; Carstens, Earl ; Antognini, Joseph F. / The effect of isoflurane and halothane on electroencephalographic activation elicited by repetitive noxious c-fiber stimulation. In: Neuroscience Letters. 2005 ; Vol. 382, No. 3. pp. 242-247.
@article{367dcacee267423c97e0c5911b2c8335,
title = "The effect of isoflurane and halothane on electroencephalographic activation elicited by repetitive noxious c-fiber stimulation",
abstract = "Windup is the progressive increase in neuronal response to a repetitive noxious stimulus. This response is most often observed in the spinal cord, but it is unclear how this response is manifested in supraspinal structures. We investigated the effects of isoflurane and halothane on electroencephalographic responses to repetitive noxious electrical stimuli (20 pulses at 0.1, 1 and 3 Hz) applied to the tail in rats. Halothane and isoflurane concentrations were adjusted to 0.8 and 1.2 minimum alveolar concentration (MAC), where MAC is the concentration needed to prevent gross and purposeful movement in 50{\%} of animals. At 0.8 MAC halothane, the 3 Hz stimulus caused electroencephalographic (EEG) activation primarily by increasing the median edge frequency (MEF), while at 1.2 MAC halothane the spectral edge frequency (SEF) was increased by the 1 and 3 Hz stimuli, and the MEF was increased by the 3 Hz stimuli. At 0.8 MAC isoflurane, the 1 and 3 Hz stimuli evoked EEG activation by increasing the MEF and SEF, while at 1.2 MAC only the MEF was increased by the 1 Hz stimulus. No EEG activation occurred with the 0.1 Hz repetitive stimulus with either isoflurane or halothane. These data suggest that repetitive electrical stimulation normally associated with windup in spinal neurons can evoke EEG activation.",
keywords = "Electroencephalography, Halothane, Isoflurane, Windup",
author = "Barter, {Linda S} and Dominguez, {Carmen L.} and Earl Carstens and Antognini, {Joseph F.}",
year = "2005",
month = "7",
day = "15",
doi = "10.1016/j.neulet.2005.03.017",
language = "English (US)",
volume = "382",
pages = "242--247",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - The effect of isoflurane and halothane on electroencephalographic activation elicited by repetitive noxious c-fiber stimulation

AU - Barter, Linda S

AU - Dominguez, Carmen L.

AU - Carstens, Earl

AU - Antognini, Joseph F.

PY - 2005/7/15

Y1 - 2005/7/15

N2 - Windup is the progressive increase in neuronal response to a repetitive noxious stimulus. This response is most often observed in the spinal cord, but it is unclear how this response is manifested in supraspinal structures. We investigated the effects of isoflurane and halothane on electroencephalographic responses to repetitive noxious electrical stimuli (20 pulses at 0.1, 1 and 3 Hz) applied to the tail in rats. Halothane and isoflurane concentrations were adjusted to 0.8 and 1.2 minimum alveolar concentration (MAC), where MAC is the concentration needed to prevent gross and purposeful movement in 50% of animals. At 0.8 MAC halothane, the 3 Hz stimulus caused electroencephalographic (EEG) activation primarily by increasing the median edge frequency (MEF), while at 1.2 MAC halothane the spectral edge frequency (SEF) was increased by the 1 and 3 Hz stimuli, and the MEF was increased by the 3 Hz stimuli. At 0.8 MAC isoflurane, the 1 and 3 Hz stimuli evoked EEG activation by increasing the MEF and SEF, while at 1.2 MAC only the MEF was increased by the 1 Hz stimulus. No EEG activation occurred with the 0.1 Hz repetitive stimulus with either isoflurane or halothane. These data suggest that repetitive electrical stimulation normally associated with windup in spinal neurons can evoke EEG activation.

AB - Windup is the progressive increase in neuronal response to a repetitive noxious stimulus. This response is most often observed in the spinal cord, but it is unclear how this response is manifested in supraspinal structures. We investigated the effects of isoflurane and halothane on electroencephalographic responses to repetitive noxious electrical stimuli (20 pulses at 0.1, 1 and 3 Hz) applied to the tail in rats. Halothane and isoflurane concentrations were adjusted to 0.8 and 1.2 minimum alveolar concentration (MAC), where MAC is the concentration needed to prevent gross and purposeful movement in 50% of animals. At 0.8 MAC halothane, the 3 Hz stimulus caused electroencephalographic (EEG) activation primarily by increasing the median edge frequency (MEF), while at 1.2 MAC halothane the spectral edge frequency (SEF) was increased by the 1 and 3 Hz stimuli, and the MEF was increased by the 3 Hz stimuli. At 0.8 MAC isoflurane, the 1 and 3 Hz stimuli evoked EEG activation by increasing the MEF and SEF, while at 1.2 MAC only the MEF was increased by the 1 Hz stimulus. No EEG activation occurred with the 0.1 Hz repetitive stimulus with either isoflurane or halothane. These data suggest that repetitive electrical stimulation normally associated with windup in spinal neurons can evoke EEG activation.

KW - Electroencephalography

KW - Halothane

KW - Isoflurane

KW - Windup

UR - http://www.scopus.com/inward/record.url?scp=19544375973&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19544375973&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2005.03.017

DO - 10.1016/j.neulet.2005.03.017

M3 - Article

C2 - 15925098

AN - SCOPUS:19544375973

VL - 382

SP - 242

EP - 247

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3

ER -