The effect of interferon-gamma intramammary administration on mammary phagocyte function.

L. K. Fox, H. D. Liggit, Tilahun Yilma, L. B. Corbeil

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effect of recombinant bovine interferon-gamma on intramammary phagocyte function of mammary gland was studied in 4 Holstein cows (Study 1) and 7 Holstein cows (Study 2). Recombinant bovine interferon-gamma was intramammarily infused on day 6 of the dry period and phagocytes were collected from lacteal secretions and tested in vitro 24 hours later. Results from Study 1 indicate that phagocytosis of Escherichia coli and Staphylococcus aureus was significantly increased after than before interferon treatment. Similarly, the number of bacteria killed/active phagocyte was enhanced by treatment. Results from Study 2 suggested a trend towards increased production of oxygen dependent bactericidal components and increased killing ability by phagocytes exposed to interferon as compared to control phagocytes. These results from both studies suggest that intramammary infusions of bovine interferon-gamma can stimulate phagocyte function during the early phase of the dry period.

Original languageEnglish (US)
Pages (from-to)28-30
Number of pages3
JournalZentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B
Volume37
Issue number1
StatePublished - Feb 1990
Externally publishedYes

Fingerprint

phagocytes
Phagocytes
interferon-gamma
Interferon-gamma
breasts
Breast
dry period (lactation)
interferons
Interferons
cattle
Holstein
mammary gland function
milk secretion
cows
Human Mammary Glands
phagocytosis
Phagocytosis
Staphylococcus aureus
Milk
Oxygen

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The effect of interferon-gamma intramammary administration on mammary phagocyte function. / Fox, L. K.; Liggit, H. D.; Yilma, Tilahun; Corbeil, L. B.

In: Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B, Vol. 37, No. 1, 02.1990, p. 28-30.

Research output: Contribution to journalArticle

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