Abstract
The effect of recombinant bovine interferon-gamma on intramammary phagocyte function of mammary gland was studied in 4 Holstein cows (Study 1) and 7 Holstein cows (Study 2). Recombinant bovine interferon-gamma was intramammarily infused on day 6 of the dry period and phagocytes were collected from lacteal secretions and tested in vitro 24 hours later. Results from Study 1 indicate that phagocytosis of Escherichia coli and Staphylococcus aureus was significantly increased after than before interferon treatment. Similarly, the number of bacteria killed/active phagocyte was enhanced by treatment. Results from Study 2 suggested a trend towards increased production of oxygen dependent bactericidal components and increased killing ability by phagocytes exposed to interferon as compared to control phagocytes. These results from both studies suggest that intramammary infusions of bovine interferon-gamma can stimulate phagocyte function during the early phase of the dry period.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 28-30 |
| Number of pages | 3 |
| Journal | Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B |
| Volume | 37 |
| Issue number | 1 |
| State | Published - Feb 1990 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
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The effect of interferon-gamma intramammary administration on mammary phagocyte function. / Fox, L. K.; Liggit, H. D.; Yilma, Tilahun; Corbeil, L. B.
In: Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B, Vol. 37, No. 1, 02.1990, p. 28-30.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of interferon-gamma intramammary administration on mammary phagocyte function.
AU - Fox, L. K.
AU - Liggit, H. D.
AU - Yilma, Tilahun
AU - Corbeil, L. B.
PY - 1990/2
Y1 - 1990/2
N2 - The effect of recombinant bovine interferon-gamma on intramammary phagocyte function of mammary gland was studied in 4 Holstein cows (Study 1) and 7 Holstein cows (Study 2). Recombinant bovine interferon-gamma was intramammarily infused on day 6 of the dry period and phagocytes were collected from lacteal secretions and tested in vitro 24 hours later. Results from Study 1 indicate that phagocytosis of Escherichia coli and Staphylococcus aureus was significantly increased after than before interferon treatment. Similarly, the number of bacteria killed/active phagocyte was enhanced by treatment. Results from Study 2 suggested a trend towards increased production of oxygen dependent bactericidal components and increased killing ability by phagocytes exposed to interferon as compared to control phagocytes. These results from both studies suggest that intramammary infusions of bovine interferon-gamma can stimulate phagocyte function during the early phase of the dry period.
AB - The effect of recombinant bovine interferon-gamma on intramammary phagocyte function of mammary gland was studied in 4 Holstein cows (Study 1) and 7 Holstein cows (Study 2). Recombinant bovine interferon-gamma was intramammarily infused on day 6 of the dry period and phagocytes were collected from lacteal secretions and tested in vitro 24 hours later. Results from Study 1 indicate that phagocytosis of Escherichia coli and Staphylococcus aureus was significantly increased after than before interferon treatment. Similarly, the number of bacteria killed/active phagocyte was enhanced by treatment. Results from Study 2 suggested a trend towards increased production of oxygen dependent bactericidal components and increased killing ability by phagocytes exposed to interferon as compared to control phagocytes. These results from both studies suggest that intramammary infusions of bovine interferon-gamma can stimulate phagocyte function during the early phase of the dry period.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025382484&partnerID=8YFLogxK
M3 - Article
C2 - 2111962
AN - SCOPUS:0025382484
VL - 37
SP - 28
EP - 30
JO - Journal of Veterinary Medicine Series B: Infectious Diseases and Veterinary Public Health
JF - Journal of Veterinary Medicine Series B: Infectious Diseases and Veterinary Public Health
SN - 1863-1959
IS - 1
ER -