The Effect of Increased Frequency of Hemodialysis on Volume-Related Outcomes: A Secondary Analysis of the Frequent Hemodialysis Network Trials

Jochen G. Raimann, Christopher T. Chan, John T. Daugirdas, Tom Depner, Frank A. Gotch, Tom Greene, George Kaysen, Alan S. Kliger, Peter Kotanko, Brett Larive, Robert Lindsay, Michael V. Rocco, Glenn M. Chertow, Nathan W. Levin

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In previous reports of the Frequent Hemodialysis Network trials, frequent hemodialysis (HD) reduced extracellular fluid (ECF) and left ventricular mass (LVM), with more pronounced effects observed among patients with low urine volume (UVol). We analyzed the effect of frequent HD on interdialytic weight gain (IDWG) and a time-integrated estimate of ECF load (TIFL). We also explored whether volume and sodium loading contributed to the change in LVM over the study period. Treatment effects on volume parameters were analyzed for modification by UVol and the dialysate-to-serum sodium gradient. Predictors of change in LVM were determined using linear regression. Frequent HD reduced IDWG and TIFL in the Daily Trial. Among patients with UVol

Original languageEnglish (US)
Pages (from-to)277-286
Number of pages10
JournalBlood Purification
DOIs
StateAccepted/In press - Jan 21 2016

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Renal Dialysis
Extracellular Fluid
Urine
Weight Gain
Sodium
Dialysis Solutions
Linear Models
Serum
Therapeutics

Keywords

  • Clinical trials
  • Fluid overload#
  • Frequent Hemodialysis Network
  • Hemodialysis
  • Left ventricular mass

ASJC Scopus subject areas

  • Nephrology
  • Hematology

Cite this

Raimann, J. G., Chan, C. T., Daugirdas, J. T., Depner, T., Gotch, F. A., Greene, T., ... Levin, N. W. (Accepted/In press). The Effect of Increased Frequency of Hemodialysis on Volume-Related Outcomes: A Secondary Analysis of the Frequent Hemodialysis Network Trials. Blood Purification, 277-286. https://doi.org/10.1159/000441966

The Effect of Increased Frequency of Hemodialysis on Volume-Related Outcomes : A Secondary Analysis of the Frequent Hemodialysis Network Trials. / Raimann, Jochen G.; Chan, Christopher T.; Daugirdas, John T.; Depner, Tom; Gotch, Frank A.; Greene, Tom; Kaysen, George; Kliger, Alan S.; Kotanko, Peter; Larive, Brett; Lindsay, Robert; Rocco, Michael V.; Chertow, Glenn M.; Levin, Nathan W.

In: Blood Purification, 21.01.2016, p. 277-286.

Research output: Contribution to journalArticle

Raimann, JG, Chan, CT, Daugirdas, JT, Depner, T, Gotch, FA, Greene, T, Kaysen, G, Kliger, AS, Kotanko, P, Larive, B, Lindsay, R, Rocco, MV, Chertow, GM & Levin, NW 2016, 'The Effect of Increased Frequency of Hemodialysis on Volume-Related Outcomes: A Secondary Analysis of the Frequent Hemodialysis Network Trials', Blood Purification, pp. 277-286. https://doi.org/10.1159/000441966
Raimann, Jochen G. ; Chan, Christopher T. ; Daugirdas, John T. ; Depner, Tom ; Gotch, Frank A. ; Greene, Tom ; Kaysen, George ; Kliger, Alan S. ; Kotanko, Peter ; Larive, Brett ; Lindsay, Robert ; Rocco, Michael V. ; Chertow, Glenn M. ; Levin, Nathan W. / The Effect of Increased Frequency of Hemodialysis on Volume-Related Outcomes : A Secondary Analysis of the Frequent Hemodialysis Network Trials. In: Blood Purification. 2016 ; pp. 277-286.
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