The Effect of Increased Frequency of Hemodialysis on Volume-Related Outcomes: A Secondary Analysis of the Frequent Hemodialysis Network Trials

Jochen G. Raimann, Christopher T. Chan, John T. Daugirdas, Tom Depner, Frank A. Gotch, Tom Greene, George Kaysen, Alan S. Kliger, Peter Kotanko, Brett Larive, Robert Lindsay, Michael V. Rocco, Glenn M. Chertow, Nathan W. Levin

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

In previous reports of the Frequent Hemodialysis Network trials, frequent hemodialysis (HD) reduced extracellular fluid (ECF) and left ventricular mass (LVM), with more pronounced effects observed among patients with low urine volume (UVol). We analyzed the effect of frequent HD on interdialytic weight gain (IDWG) and a time-integrated estimate of ECF load (TIFL). We also explored whether volume and sodium loading contributed to the change in LVM over the study period. Treatment effects on volume parameters were analyzed for modification by UVol and the dialysate-to-serum sodium gradient. Predictors of change in LVM were determined using linear regression. Frequent HD reduced IDWG and TIFL in the Daily Trial. Among patients with UVol

Original languageEnglish (US)
Pages (from-to)277-286
Number of pages10
JournalBlood Purification
DOIs
StateAccepted/In press - Jan 21 2016

Keywords

  • Clinical trials
  • Fluid overload#
  • Frequent Hemodialysis Network
  • Hemodialysis
  • Left ventricular mass

ASJC Scopus subject areas

  • Nephrology
  • Hematology

Fingerprint Dive into the research topics of 'The Effect of Increased Frequency of Hemodialysis on Volume-Related Outcomes: A Secondary Analysis of the Frequent Hemodialysis Network Trials'. Together they form a unique fingerprint.

Cite this