The effect of hydration status on the echocardiographic measurements of normal cats

F. E. Campbell, Mark D Kittleson

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Background: Diagnosis of cardiomyopathy of cats is based on 2-dimensional (2D) echocardiography. However, circulating fluid volume largely determines diastolic cardiac chamber dimensions, and reduced diastolic volume in other species results in what has been called "pseudohypertrophy of the ventricular myocardium." Hypothesis: Altered hydration produces changes on 2D echocardiography that may confound the diagnosis or severity assessment of cardiomyopathy of cats. Animals: Ten normal colony-sourced mixed breed cats were included. Methods: Cats were examined by echocardiography at baseline and at completion of 3 protocols (volume depletion and maintenance-rate and anesthetic-rate IV fluid administration) applied in randomized crossover design with a 6-7 day washout period. Results: Volume depletion increased diastolic left ventricular interventricular septal (IVSd) and free wall diameter (4.5 ± 0.4 to 5.8 ± 0.6 mm; P < .001) with wall thickness exceeding 6 mm in 4 cats. Diastolic left ventricular internal diameter (LVIDd) decreased, and reduction in systolic left ventricular internal diameter (LVIDs) produced end-systolic cavity obliteration in 7 cats. Left-atrial-to-aortic-root ratio (LA : Ao, 1.4 ± 0.2 to 1.2 ± 0.1, P < .05) and left atrial area in diastole (LAAd) decreased with volume depletion. Maintenance-rate IV fluid administration increased LAAd and fractional shortening (FS%). Anesthetic-rate IV fluid administration increased LVIDd, FS%, LAAd, and LA: Ao ratios (to 1.7 ± 0.1, P < .01), producing an LA : Ao ratio above normal limits in 6 cats. A systolic heart murmur developed with administration of fluid at maintenance (n = 1) and anesthetic rates (n = 6). Conclusions: Altered hydration status produces changes in the echocardiographic examination of normal cats that may lead to an erroneous diagnosis of cardiomyopathy or mask its presence. Hydration status should be considered during echocardiographic examination in cats.

Original languageEnglish (US)
Pages (from-to)1008-1015
Number of pages8
JournalJournal of Veterinary Internal Medicine
Volume21
Issue number5
DOIs
StatePublished - Sep 2007

Fingerprint

Cats
cats
Diastole
cardiomyopathy
echocardiography
Cardiomyopathies
anesthetics
Echocardiography
Anesthetics
Maintenance
shortenings
Systolic Murmurs
Heart Murmurs
Masks
myocardium
aorta
Cross-Over Studies
Myocardium
heart
fluids

Keywords

  • Dehydration
  • Fluid administration
  • Heart murmur
  • Pseudohypertrophy
  • Volume depletion

ASJC Scopus subject areas

  • veterinary(all)

Cite this

The effect of hydration status on the echocardiographic measurements of normal cats. / Campbell, F. E.; Kittleson, Mark D.

In: Journal of Veterinary Internal Medicine, Vol. 21, No. 5, 09.2007, p. 1008-1015.

Research output: Contribution to journalArticle

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abstract = "Background: Diagnosis of cardiomyopathy of cats is based on 2-dimensional (2D) echocardiography. However, circulating fluid volume largely determines diastolic cardiac chamber dimensions, and reduced diastolic volume in other species results in what has been called {"}pseudohypertrophy of the ventricular myocardium.{"} Hypothesis: Altered hydration produces changes on 2D echocardiography that may confound the diagnosis or severity assessment of cardiomyopathy of cats. Animals: Ten normal colony-sourced mixed breed cats were included. Methods: Cats were examined by echocardiography at baseline and at completion of 3 protocols (volume depletion and maintenance-rate and anesthetic-rate IV fluid administration) applied in randomized crossover design with a 6-7 day washout period. Results: Volume depletion increased diastolic left ventricular interventricular septal (IVSd) and free wall diameter (4.5 ± 0.4 to 5.8 ± 0.6 mm; P < .001) with wall thickness exceeding 6 mm in 4 cats. Diastolic left ventricular internal diameter (LVIDd) decreased, and reduction in systolic left ventricular internal diameter (LVIDs) produced end-systolic cavity obliteration in 7 cats. Left-atrial-to-aortic-root ratio (LA : Ao, 1.4 ± 0.2 to 1.2 ± 0.1, P < .05) and left atrial area in diastole (LAAd) decreased with volume depletion. Maintenance-rate IV fluid administration increased LAAd and fractional shortening (FS{\%}). Anesthetic-rate IV fluid administration increased LVIDd, FS{\%}, LAAd, and LA: Ao ratios (to 1.7 ± 0.1, P < .01), producing an LA : Ao ratio above normal limits in 6 cats. A systolic heart murmur developed with administration of fluid at maintenance (n = 1) and anesthetic rates (n = 6). Conclusions: Altered hydration status produces changes in the echocardiographic examination of normal cats that may lead to an erroneous diagnosis of cardiomyopathy or mask its presence. Hydration status should be considered during echocardiographic examination in cats.",
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AB - Background: Diagnosis of cardiomyopathy of cats is based on 2-dimensional (2D) echocardiography. However, circulating fluid volume largely determines diastolic cardiac chamber dimensions, and reduced diastolic volume in other species results in what has been called "pseudohypertrophy of the ventricular myocardium." Hypothesis: Altered hydration produces changes on 2D echocardiography that may confound the diagnosis or severity assessment of cardiomyopathy of cats. Animals: Ten normal colony-sourced mixed breed cats were included. Methods: Cats were examined by echocardiography at baseline and at completion of 3 protocols (volume depletion and maintenance-rate and anesthetic-rate IV fluid administration) applied in randomized crossover design with a 6-7 day washout period. Results: Volume depletion increased diastolic left ventricular interventricular septal (IVSd) and free wall diameter (4.5 ± 0.4 to 5.8 ± 0.6 mm; P < .001) with wall thickness exceeding 6 mm in 4 cats. Diastolic left ventricular internal diameter (LVIDd) decreased, and reduction in systolic left ventricular internal diameter (LVIDs) produced end-systolic cavity obliteration in 7 cats. Left-atrial-to-aortic-root ratio (LA : Ao, 1.4 ± 0.2 to 1.2 ± 0.1, P < .05) and left atrial area in diastole (LAAd) decreased with volume depletion. Maintenance-rate IV fluid administration increased LAAd and fractional shortening (FS%). Anesthetic-rate IV fluid administration increased LVIDd, FS%, LAAd, and LA: Ao ratios (to 1.7 ± 0.1, P < .01), producing an LA : Ao ratio above normal limits in 6 cats. A systolic heart murmur developed with administration of fluid at maintenance (n = 1) and anesthetic rates (n = 6). Conclusions: Altered hydration status produces changes in the echocardiographic examination of normal cats that may lead to an erroneous diagnosis of cardiomyopathy or mask its presence. Hydration status should be considered during echocardiographic examination in cats.

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