The effect of haloperidol in cocaine and amphetamine intoxication

Robert W. Derlet, Timothy E Albertson, Pam Rice

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The effectiveness of haloperidol pretreatment in preventing the toxic effects of high doses of amphetamine and cocaine was studied in rats. In this model, toxic effects were induced by intraperitoneal (i.p.) injection of amphetamine 75 mg/kg (100% death rate) or cocaine 70 mg/kg (82% death rate). Haloperidol failed to prevent amphetamine-induced seizures, but did lower the mortality rate at most doses tested. Haloperidol decreased the incidence of cocaine-induced seizures at the two highest doses, but the lowering of the mortality rate did not reach statistical significance at any dose. These data suggest a protective role for the central dopamine blocker haloperidol against death from high-dose amphetamine exposure without reducing the incidence of seizures. In contrast, haloperidol demonstrated an ability to reduce cocaine-induced seizures without significantly reducing mortality.

Original languageEnglish (US)
Pages (from-to)633-637
Number of pages5
JournalJournal of Emergency Medicine
Volume7
Issue number6
DOIs
StatePublished - 1989

Keywords

  • amphetamine
  • cocaine
  • haloperidol
  • rats
  • seizures

ASJC Scopus subject areas

  • Emergency Medicine

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