The effect of exogenous GM1 ganglioside on kindled-amygdaloid seizures

Timothy E Albertson, W. F. Walby

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The effects of 12 daily doses of 30mg/kg GM1 ganglioside i.p. on the acquisition of kindled-amygdaloid seizures in the rat was studied. No modification in the rate of kindling or the expression of the elicited seizures was noted during the acquisition phase. Further studies with additional fully amygdaloid kindled rats failed to show significant modification of suprathreshold or threshold elicited seizures after single 30-60mg/kg i.p. doses of GM1 ganglioside. Despite previous studies which have shown antibodies to GM1 ganglioside to be convulsive, no anticonvul sant activity was demonstrated in this study with exogenous GM1 ganglioside using a battery of kindled-amygdaloid seizure tests in the rat.

Original languageEnglish (US)
Pages (from-to)261-264
Number of pages4
JournalNeuropharmacology
Volume26
Issue number2-3
DOIs
StatePublished - 1987

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Keywords

  • Amygdala
  • ganglioside
  • GM
  • kindling
  • seizures

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

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