Abstract
One thousand neonatal calves, allocated in a factorial design into four groups, were vaccinated subcutaneously with two doses each of either killed Escherichia coli (O111:B4) J5 bacterin or a UC Davis modified live, genetically altered (aro-) Salmonella dublin vaccine, or both, or with a placebo. In this prospective double-blind study to determine the immunogenicity and protective effects of both vaccines on bovine neonates in field conditions, calves were observed daily until 2 months of age, and serum samples from selected study calves were obtained at five different time points. No clinical adverse vaccine reactions were observed. Overall mortality was 7.5% (75 of 1000), E. coli and S. dublin infection being the most commonly associated aetiological agents of deaths. Both J5 (p<0.01) and Salmonella (p=0.05) vaccines were significantly effective in reducing the mortality rate but without an additive effect. The role of passive transfer was important in calf survival. The E. coli J5 and (aro-) S. dublin vaccination schedule employed significantly (p<0.001) elevated J5 and Salmonella-specific serum ELISA antibody titres, respectively, by the sixth week of age.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 381-390 |
| Number of pages | 10 |
| Journal | Vaccine |
| Volume | 13 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1995 |
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Keywords
- calf
- E. coli J5
- immunoglobulin
- neonatal immunity
- Salmonella
- vaccine
ASJC Scopus subject areas
- Molecular Medicine
- Immunology and Microbiology(all)
- Infectious Diseases
- Public Health, Environmental and Occupational Health
- veterinary(all)
- Immunology
- Microbiology
- Virology
Cite this
The effect of Escherichia coli J5 and modified live Salmonella dublin vaccines in artificially reared neonatal calves. / Selim, Sheikh A.; Cullor, James S; Smith, Bradford; Blanchard, Patricia C; Farver, Thomas B; Hoffman, Richard; Dilling, George; Roden, Lin Da; Wilgenburg, Bert.
In: Vaccine, Vol. 13, No. 4, 1995, p. 381-390.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of Escherichia coli J5 and modified live Salmonella dublin vaccines in artificially reared neonatal calves
AU - Selim, Sheikh A.
AU - Cullor, James S
AU - Smith, Bradford
AU - Blanchard, Patricia C
AU - Farver, Thomas B
AU - Hoffman, Richard
AU - Dilling, George
AU - Roden, Lin Da
AU - Wilgenburg, Bert
PY - 1995
Y1 - 1995
N2 - One thousand neonatal calves, allocated in a factorial design into four groups, were vaccinated subcutaneously with two doses each of either killed Escherichia coli (O111:B4) J5 bacterin or a UC Davis modified live, genetically altered (aro-) Salmonella dublin vaccine, or both, or with a placebo. In this prospective double-blind study to determine the immunogenicity and protective effects of both vaccines on bovine neonates in field conditions, calves were observed daily until 2 months of age, and serum samples from selected study calves were obtained at five different time points. No clinical adverse vaccine reactions were observed. Overall mortality was 7.5% (75 of 1000), E. coli and S. dublin infection being the most commonly associated aetiological agents of deaths. Both J5 (p<0.01) and Salmonella (p=0.05) vaccines were significantly effective in reducing the mortality rate but without an additive effect. The role of passive transfer was important in calf survival. The E. coli J5 and (aro-) S. dublin vaccination schedule employed significantly (p<0.001) elevated J5 and Salmonella-specific serum ELISA antibody titres, respectively, by the sixth week of age.
AB - One thousand neonatal calves, allocated in a factorial design into four groups, were vaccinated subcutaneously with two doses each of either killed Escherichia coli (O111:B4) J5 bacterin or a UC Davis modified live, genetically altered (aro-) Salmonella dublin vaccine, or both, or with a placebo. In this prospective double-blind study to determine the immunogenicity and protective effects of both vaccines on bovine neonates in field conditions, calves were observed daily until 2 months of age, and serum samples from selected study calves were obtained at five different time points. No clinical adverse vaccine reactions were observed. Overall mortality was 7.5% (75 of 1000), E. coli and S. dublin infection being the most commonly associated aetiological agents of deaths. Both J5 (p<0.01) and Salmonella (p=0.05) vaccines were significantly effective in reducing the mortality rate but without an additive effect. The role of passive transfer was important in calf survival. The E. coli J5 and (aro-) S. dublin vaccination schedule employed significantly (p<0.001) elevated J5 and Salmonella-specific serum ELISA antibody titres, respectively, by the sixth week of age.
KW - calf
KW - E. coli J5
KW - immunoglobulin
KW - neonatal immunity
KW - Salmonella
KW - vaccine
UR - http://www.scopus.com/inward/record.url?scp=0028908168&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028908168&partnerID=8YFLogxK
U2 - 10.1016/0264-410X(95)98262-9
DO - 10.1016/0264-410X(95)98262-9
M3 - Article
VL - 13
SP - 381
EP - 390
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 4
ER -