The effect of Escherichia coli J5 and modified live Salmonella dublin vaccines in artificially reared neonatal calves

Sheikh A. Selim, James S Cullor, Bradford Smith, Patricia C Blanchard, Thomas B Farver, Richard Hoffman, George Dilling, Lin Da Roden, Bert Wilgenburg

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

One thousand neonatal calves, allocated in a factorial design into four groups, were vaccinated subcutaneously with two doses each of either killed Escherichia coli (O111:B4) J5 bacterin or a UC Davis modified live, genetically altered (aro-) Salmonella dublin vaccine, or both, or with a placebo. In this prospective double-blind study to determine the immunogenicity and protective effects of both vaccines on bovine neonates in field conditions, calves were observed daily until 2 months of age, and serum samples from selected study calves were obtained at five different time points. No clinical adverse vaccine reactions were observed. Overall mortality was 7.5% (75 of 1000), E. coli and S. dublin infection being the most commonly associated aetiological agents of deaths. Both J5 (p<0.01) and Salmonella (p=0.05) vaccines were significantly effective in reducing the mortality rate but without an additive effect. The role of passive transfer was important in calf survival. The E. coli J5 and (aro-) S. dublin vaccination schedule employed significantly (p<0.001) elevated J5 and Salmonella-specific serum ELISA antibody titres, respectively, by the sixth week of age.

Original languageEnglish (US)
Pages (from-to)381-390
Number of pages10
JournalVaccine
Volume13
Issue number4
DOIs
StatePublished - 1995

Fingerprint

Salmonella Vaccines
Salmonella Dublin
Vaccines
calves
vaccines
Escherichia coli
Salmonella
Bacterial Vaccines
Mortality
Serum
Double-Blind Method
etiological agents
Appointments and Schedules
Vaccination
Enzyme-Linked Immunosorbent Assay
additive effect
Placebos
placebos
protective effect
neonates

Keywords

  • calf
  • E. coli J5
  • immunoglobulin
  • neonatal immunity
  • Salmonella
  • vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Immunology
  • Microbiology
  • Virology

Cite this

The effect of Escherichia coli J5 and modified live Salmonella dublin vaccines in artificially reared neonatal calves. / Selim, Sheikh A.; Cullor, James S; Smith, Bradford; Blanchard, Patricia C; Farver, Thomas B; Hoffman, Richard; Dilling, George; Roden, Lin Da; Wilgenburg, Bert.

In: Vaccine, Vol. 13, No. 4, 1995, p. 381-390.

Research output: Contribution to journalArticle

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