The effect of Escherichia coli J5 and modified live Salmonella dublin vaccines in artificially reared neonatal calves

Sheikh A. Selim, James S. Cullor, Bradford P. Smith, Patricia Blanchard, Thomas B. Farver, Richard Hoffman, George Dilling, Lin Da Roden, Bert Wilgenburg

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

One thousand neonatal calves, allocated in a factorial design into four groups, were vaccinated subcutaneously with two doses each of either killed Escherichia coli (O111:B4) J5 bacterin or a UC Davis modified live, genetically altered (aro-) Salmonella dublin vaccine, or both, or with a placebo. In this prospective double-blind study to determine the immunogenicity and protective effects of both vaccines on bovine neonates in field conditions, calves were observed daily until 2 months of age, and serum samples from selected study calves were obtained at five different time points. No clinical adverse vaccine reactions were observed. Overall mortality was 7.5% (75 of 1000), E. coli and S. dublin infection being the most commonly associated aetiological agents of deaths. Both J5 (p<0.01) and Salmonella (p=0.05) vaccines were significantly effective in reducing the mortality rate but without an additive effect. The role of passive transfer was important in calf survival. The E. coli J5 and (aro-) S. dublin vaccination schedule employed significantly (p<0.001) elevated J5 and Salmonella-specific serum ELISA antibody titres, respectively, by the sixth week of age.

Original languageEnglish (US)
Pages (from-to)381-390
Number of pages10
JournalVaccine
Volume13
Issue number4
DOIs
StatePublished - 1995

Keywords

  • calf
  • E. coli J5
  • immunoglobulin
  • neonatal immunity
  • Salmonella
  • vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Immunology
  • Microbiology
  • Virology

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