The effect of doxapram-induced hyperventilation on respiratory mechanics in horses

E. Aguilera-Tejero, J. R. Pascoe, B. L. Smith, M. J. Woliner

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


To investigate the influence of increased respiratory frequency on respiratory mechanics in the horse, measurements were made in two groups of seven tracheostomised horses before and after the administration of doxapram. The horses in group I had normal base line values for respiratory mechanics, whereas the horses in group II had significantly lower values of dynamic compliance (Cdyn), higher respiratory resistance (R), and a higher total change in pleural pressure (ΔP). The administration of 0·3 mg kg-1 doxapram intravenously resulted in a significant increase in respiratory frequency (fR), R, ΔP, tidal volume (VT), and peak to peak respiratory flow (V̇), and a decrease in Cdyn in both groups of horses. The group II horses had significantly greater increases in R and ΔP than the horses in group I.

Original languageEnglish (US)
Pages (from-to)143-146
Number of pages4
JournalResearch in Veterinary Science
Issue number2
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • veterinary(all)


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