Abstract
To investigate the influence of increased respiratory frequency on respiratory mechanics in the horse, measurements were made in two groups of seven tracheostomised horses before and after the administration of doxapram. The horses in group I had normal base line values for respiratory mechanics, whereas the horses in group II had significantly lower values of dynamic compliance (Cdyn), higher respiratory resistance (R), and a higher total change in pleural pressure (ΔP). The administration of 0·3 mg kg-1 doxapram intravenously resulted in a significant increase in respiratory frequency (fR), R, ΔP, tidal volume (VT), and peak to peak respiratory flow (V̇), and a decrease in Cdyn in both groups of horses. The group II horses had significantly greater increases in R and ΔP than the horses in group I.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 143-146 |
| Number of pages | 4 |
| Journal | Research in Veterinary Science |
| Volume | 62 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1997 |
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ASJC Scopus subject areas
- veterinary(all)
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The effect of doxapram-induced hyperventilation on respiratory mechanics in horses. / Aguilera-Tejero, E.; Pascoe, John; Smith, B. L.; Woliner, M. J.
In: Research in Veterinary Science, Vol. 62, No. 2, 01.01.1997, p. 143-146.Research output: Contribution to journal › Article
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TY - JOUR
T1 - The effect of doxapram-induced hyperventilation on respiratory mechanics in horses
AU - Aguilera-Tejero, E.
AU - Pascoe, John
AU - Smith, B. L.
AU - Woliner, M. J.
PY - 1997/1/1
Y1 - 1997/1/1
N2 - To investigate the influence of increased respiratory frequency on respiratory mechanics in the horse, measurements were made in two groups of seven tracheostomised horses before and after the administration of doxapram. The horses in group I had normal base line values for respiratory mechanics, whereas the horses in group II had significantly lower values of dynamic compliance (Cdyn), higher respiratory resistance (R), and a higher total change in pleural pressure (ΔP). The administration of 0·3 mg kg-1 doxapram intravenously resulted in a significant increase in respiratory frequency (fR), R, ΔP, tidal volume (VT), and peak to peak respiratory flow (V̇), and a decrease in Cdyn in both groups of horses. The group II horses had significantly greater increases in R and ΔP than the horses in group I.
AB - To investigate the influence of increased respiratory frequency on respiratory mechanics in the horse, measurements were made in two groups of seven tracheostomised horses before and after the administration of doxapram. The horses in group I had normal base line values for respiratory mechanics, whereas the horses in group II had significantly lower values of dynamic compliance (Cdyn), higher respiratory resistance (R), and a higher total change in pleural pressure (ΔP). The administration of 0·3 mg kg-1 doxapram intravenously resulted in a significant increase in respiratory frequency (fR), R, ΔP, tidal volume (VT), and peak to peak respiratory flow (V̇), and a decrease in Cdyn in both groups of horses. The group II horses had significantly greater increases in R and ΔP than the horses in group I.
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UR - http://www.scopus.com/inward/citedby.url?scp=0031086822&partnerID=8YFLogxK
U2 - 10.1016/S0034-5288(97)90136-3
DO - 10.1016/S0034-5288(97)90136-3
M3 - Article
C2 - 9243713
AN - SCOPUS:0031086822
VL - 62
SP - 143
EP - 146
JO - Research in Veterinary Science
JF - Research in Veterinary Science
SN - 0034-5288
IS - 2
ER -