The effect of donor specific transfusions and dietary fatty acids on rat cardiac allograft survival

Richard V Perez, J. Paul Waymack, Rino Munda, J. Wesley Alexander

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

A rat heterotopic cardiac transplant model was used to study the effect of dietary lipids on the immune response. Animals receiving linoleic acid (LA), oleic acid (OA), and fish oil (FO) enriched diets showed significant prolongation of allograft survival when compared to the control diet fed animals. When LA was given to animals who had received a single donor specific transfusion (DST) augmentation of the beneficial DST effect was observed, while the OA and FO fed groups showed no differences from control DST animals. Dietary regulation of the immune response, possibly through manipulation of arachidonic acid metabolism, is implied.

Original languageEnglish (US)
Pages (from-to)335-340
Number of pages6
JournalJournal of Surgical Research
Volume42
Issue number4
DOIs
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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