Abstract
In Experiment 1 rats were gavaged with ethanol and nutrients at 6 hr intervals for 72 hr. Ethanol dosages were assigned by behavioral criteria of inebriation. Nourished animals were able to tolerate higher ethanol dosages than nutrient-deprived rats (9.62 vs 7.60 g/kg/day). Nourished rats were less likely to have withdrawal seizures than were nutrient-deprived rats given an equivalent amount of ethanol, but nourished rats given 25-30% more ethanol than the nutrient-deprived rats did have withdrawal seizures. Nutrient-deprived rats had BEC's (Blood Ethanol Contents) higher than those of nourished rats receiving equivalent amounts of ethanol but comparable to the BEC's of nourished rats receiving 25-30% more ethanol. All these results were replicated in Experiment 2 in which ethanol dependent rats above starting body weight were produced after only nine ethanol doses (54 hr).
Original language | English (US) |
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Pages (from-to) | 35-46 |
Number of pages | 12 |
Journal | Addictive Behaviors |
Volume | 2 |
Issue number | 1 |
DOIs | |
State | Published - 1977 |
Externally published | Yes |
ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology