The effect of diet on ethanol withdrawal symptomatology

T. B. Baker, D. S. Cannon, Robert F Berman, C. A. Atkinson

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

In Experiment 1 rats were gavaged with ethanol and nutrients at 6 hr intervals for 72 hr. Ethanol dosages were assigned by behavioral criteria of inebriation. Nourished animals were able to tolerate higher ethanol dosages than nutrient-deprived rats (9.62 vs 7.60 g/kg/day). Nourished rats were less likely to have withdrawal seizures than were nutrient-deprived rats given an equivalent amount of ethanol, but nourished rats given 25-30% more ethanol than the nutrient-deprived rats did have withdrawal seizures. Nutrient-deprived rats had BEC's (Blood Ethanol Contents) higher than those of nourished rats receiving equivalent amounts of ethanol but comparable to the BEC's of nourished rats receiving 25-30% more ethanol. All these results were replicated in Experiment 2 in which ethanol dependent rats above starting body weight were produced after only nine ethanol doses (54 hr).

Original languageEnglish (US)
Pages (from-to)35-46
Number of pages12
JournalAddictive Behaviors
Volume2
Issue number1
DOIs
StatePublished - 1977
Externally publishedYes

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ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

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