The effect of diet on ethanol withdrawal symptomatology

T. B. Baker; D. S. Cannon; Robert F Berman; C. A. Atkinson

doi:10.1016/0306-4603(77)90007-7

The effect of diet on ethanol withdrawal symptomatology

T. B. Baker, D. S. Cannon, Robert F Berman, C. A. Atkinson

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

In Experiment 1 rats were gavaged with ethanol and nutrients at 6 hr intervals for 72 hr. Ethanol dosages were assigned by behavioral criteria of inebriation. Nourished animals were able to tolerate higher ethanol dosages than nutrient-deprived rats (9.62 vs 7.60 g/kg/day). Nourished rats were less likely to have withdrawal seizures than were nutrient-deprived rats given an equivalent amount of ethanol, but nourished rats given 25-30% more ethanol than the nutrient-deprived rats did have withdrawal seizures. Nutrient-deprived rats had BEC's (Blood Ethanol Contents) higher than those of nourished rats receiving equivalent amounts of ethanol but comparable to the BEC's of nourished rats receiving 25-30% more ethanol. All these results were replicated in Experiment 2 in which ethanol dependent rats above starting body weight were produced after only nine ethanol doses (54 hr).

Original language	English (US)
Pages (from-to)	35-46
Number of pages	12
Journal	Addictive Behaviors
Volume	2
Issue number	1
DOIs	https://doi.org/10.1016/0306-4603(77)90007-7
State	Published - 1977
Externally published	Yes

ASJC Scopus subject areas

Psychiatry and Mental health
Clinical Psychology

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title = "The effect of diet on ethanol withdrawal symptomatology",

abstract = "In Experiment 1 rats were gavaged with ethanol and nutrients at 6 hr intervals for 72 hr. Ethanol dosages were assigned by behavioral criteria of inebriation. Nourished animals were able to tolerate higher ethanol dosages than nutrient-deprived rats (9.62 vs 7.60 g/kg/day). Nourished rats were less likely to have withdrawal seizures than were nutrient-deprived rats given an equivalent amount of ethanol, but nourished rats given 25-30% more ethanol than the nutrient-deprived rats did have withdrawal seizures. Nutrient-deprived rats had BEC's (Blood Ethanol Contents) higher than those of nourished rats receiving equivalent amounts of ethanol but comparable to the BEC's of nourished rats receiving 25-30% more ethanol. All these results were replicated in Experiment 2 in which ethanol dependent rats above starting body weight were produced after only nine ethanol doses (54 hr).",

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AU - Baker, T. B.

AU - Cannon, D. S.

AU - Berman, Robert F

AU - Atkinson, C. A.

PY - 1977

Y1 - 1977

N2 - In Experiment 1 rats were gavaged with ethanol and nutrients at 6 hr intervals for 72 hr. Ethanol dosages were assigned by behavioral criteria of inebriation. Nourished animals were able to tolerate higher ethanol dosages than nutrient-deprived rats (9.62 vs 7.60 g/kg/day). Nourished rats were less likely to have withdrawal seizures than were nutrient-deprived rats given an equivalent amount of ethanol, but nourished rats given 25-30% more ethanol than the nutrient-deprived rats did have withdrawal seizures. Nutrient-deprived rats had BEC's (Blood Ethanol Contents) higher than those of nourished rats receiving equivalent amounts of ethanol but comparable to the BEC's of nourished rats receiving 25-30% more ethanol. All these results were replicated in Experiment 2 in which ethanol dependent rats above starting body weight were produced after only nine ethanol doses (54 hr).

AB - In Experiment 1 rats were gavaged with ethanol and nutrients at 6 hr intervals for 72 hr. Ethanol dosages were assigned by behavioral criteria of inebriation. Nourished animals were able to tolerate higher ethanol dosages than nutrient-deprived rats (9.62 vs 7.60 g/kg/day). Nourished rats were less likely to have withdrawal seizures than were nutrient-deprived rats given an equivalent amount of ethanol, but nourished rats given 25-30% more ethanol than the nutrient-deprived rats did have withdrawal seizures. Nutrient-deprived rats had BEC's (Blood Ethanol Contents) higher than those of nourished rats receiving equivalent amounts of ethanol but comparable to the BEC's of nourished rats receiving 25-30% more ethanol. All these results were replicated in Experiment 2 in which ethanol dependent rats above starting body weight were produced after only nine ethanol doses (54 hr).

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