The effect of diabetes on the molecular localization of maternal and fetal zinc and copper metalloprotein in the rat

Janet Y. Uriu-Hare, Judith S. Stern, Carl L Keen

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The molecular localization of maternal and fetal zinc and copper metalloproteins in diabetic and control rats was studied. Compared to controls, liver and kidneys of diabetic dams showed an increased concentration of zinc and copper that was associated with metallothionein. In contrast, fetuses of diabetic dams had lower zinc and metallothionein levels than fetuses from controls. The abnormal maternal trace element metabolism seen with diabetes resulted in alterations of zinc uptake and/or retention of their fetuses.

Original languageEnglish (US)
Pages (from-to)71-79
Number of pages9
JournalBiological Trace Element Research
Volume18
Issue number1
DOIs
StatePublished - Dec 1988

Keywords

  • copper
  • Diabetes
  • metallothionein
  • pregnancy
  • zinc

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry, medical
  • Inorganic Chemistry
  • Clinical Biochemistry
  • Biochemistry

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