The effect of copper chelating drugs on liver iron mobilization in the adult rat

Nancy L. Cohen, Carl L Keen, Bo Lönnerdal, Lucille S. Hurley

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

To test the hypothesis that ferroxidase I (ceruloplasmin) activity is essential for iron mobilization, adult rats were fed a copper sufficient diet with or without the chelating drugs D-penicillamine and triethylenetetramine for 120 days. By day 6 of treatment and for the remainder of the experiment the drug-fed rats showed low plasma copper concentration and low ferroxidase I activity. Plasma ferroxidase II activity in the DPA and TETA groups tended to be slightly lower than that of controls. No animals became anemic. Therefore, persistent low plasma ferroxidase I does not necessarily cause anemia in the adult rat.

Original languageEnglish (US)
Pages (from-to)127-134
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume113
Issue number1
DOIs
StatePublished - May 31 1983

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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