The effect of contraceptives containing nonoxynol-9 on the genital transmission of simian immunodeficiency virus in rhesus macaques

Chris J Miller, N. J. Alexander, A. Gettie, Andrew G Hendrickx, P. A. Marx

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

The ability of two nonoxynol-9 spermicide preparations to prevent the genital transmission of SIV in rhesus macaques was compared. Administration of one mL of contraceptive foam before the intravaginal inoculation of cell- free SIV prevented the genital transmission of SIV to three of six animals, and using one mL of contraceptive gel prevented the genital transmission of SIV to two of six animals. Thus, both contraceptive foams and gels containing nonoxynol-9 provided protection against the genital transmission of SIV.

Original languageEnglish (US)
Pages (from-to)1126-1128
Number of pages3
JournalFertility and Sterility
Volume57
Issue number5
StatePublished - 1992

Keywords

  • genital transmission
  • nonoxynol-9
  • Simian immunodeficiency virus

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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