The effect of chronic alcohol ingestion on free radical defense in the miniature pig

S. Zidenberg-Cherr, C. H. Halsted, K. L. Olin, A. M. Reisenauer, Carl L Keen

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Cellular protection from free radical reactions was measured in hepatic tissue from controls and miniature pigs fed ethanol. The activities of copper-zinc superoxide dismutase (CuZnSOD) and glutathione peroxidase were lower and the activity of manganese superoxide dismutase (MnSOD) was higher in the pigs fed ethanol than in controls. Glutathione concentration was lower in the pigs fed ethanol than in controls. Ethanol consumption did not result in increased lipid peroxidation as assessed by thiobarbituric acid-reactive substances. The ethanol-induced effects on the activities of the superoxide dismutases may be a reflection of available metals and/or a response to increased hepatic concentration of oxygen radicals. Because the protection afforded by the glutathione system was altered, pigs fed ethanol may be at risk of perioxidative damage with continued ethanol exposure.

Original languageEnglish (US)
Pages (from-to)213-217
Number of pages5
JournalJournal of Nutrition
Volume120
Issue number2
StatePublished - 1990

Keywords

  • Alcohol
  • Copper
  • Free radicals
  • Glutathione
  • Glutathione peroxidase
  • Manganese
  • Miniature pigs
  • Superoxide dismutase
  • Zinc

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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    Zidenberg-Cherr, S., Halsted, C. H., Olin, K. L., Reisenauer, A. M., & Keen, C. L. (1990). The effect of chronic alcohol ingestion on free radical defense in the miniature pig. Journal of Nutrition, 120(2), 213-217.