The effect of air pollution on lung development from 10 to 18 years of age

W. James Gauderman, Edward Avol, Frank Gilliland, Hita Vora, Duncan Thomas, Kiros Berhane, Rob McConnell, Nino Kuenzli, Fred Lurmann, Edward Rappaport, Helene G Margolis, David Bates, John Peters

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Abstract

BACKGROUND: Whether exposure to air pollution adversely affects the growth of lung function during the period of rapid lung development that occurs between the ages of 10 and 18 years is unknown. METHODS: In this prospective study, we recruited 1759 children (average age, 10 years) from schools in 12 southern California communities and measured lung function annually for eight years. The rate of attrition was approximately 10 percent per year. The communities represented a wide range of ambient exposures to ozone, acid vapor, nitrogen dioxide, and particulate matter. Linear regression was used to examine the relationship of air pollution to the forced expiratory volume in one second (FEV1) and other spirometric measures. RESULTS: Over the eight-year period, deficits in the growth of FEV1 were associated with exposure to nitrogen dioxide (P=0.005), acid vapor (P=0.004), particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) (P=0.04), and elemental carbon (P=0.007), even after adjustment for several potential confounders and effect modifiers. Associations were also observed for other spirometric measures. Exposure to pollutants was associated with clinically and statistically significant deficits in the FEV1 attained at the age of 18 years. For example, the estimated proportion of 18-year-old subjects with a low FEV1 (defined as a ratio of observed to expected FEV1 of less than 80 percent) was 4.9 times as great at the highest level of exposure to PM2.5 as at the lowest level of exposure (7.9 percent vs. 1.6 percent, P=0.002). CONCLUSIONS: The results of this study indicate that current levels of air pollution have chronic, adverse effects on lung development in children from the age of 10 to 18 years, leading to clinically significant deficits in attained FEV1 as children reach adulthood.

Original languageEnglish (US)
Pages (from-to)1057-1067
Number of pages11
JournalNew England Journal of Medicine
Volume351
Issue number11
DOIs
StatePublished - Sep 9 2004

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Air Pollution
Nitrogen Dioxide
Lung
Particulate Matter
Acids
Ozone
Forced Expiratory Volume
Growth
Child Development
Linear Models
Carbon
Prospective Studies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gauderman, W. J., Avol, E., Gilliland, F., Vora, H., Thomas, D., Berhane, K., ... Peters, J. (2004). The effect of air pollution on lung development from 10 to 18 years of age. New England Journal of Medicine, 351(11), 1057-1067. https://doi.org/10.1056/NEJMoa040610

The effect of air pollution on lung development from 10 to 18 years of age. / Gauderman, W. James; Avol, Edward; Gilliland, Frank; Vora, Hita; Thomas, Duncan; Berhane, Kiros; McConnell, Rob; Kuenzli, Nino; Lurmann, Fred; Rappaport, Edward; Margolis, Helene G; Bates, David; Peters, John.

In: New England Journal of Medicine, Vol. 351, No. 11, 09.09.2004, p. 1057-1067.

Research output: Contribution to journalArticle

Gauderman, WJ, Avol, E, Gilliland, F, Vora, H, Thomas, D, Berhane, K, McConnell, R, Kuenzli, N, Lurmann, F, Rappaport, E, Margolis, HG, Bates, D & Peters, J 2004, 'The effect of air pollution on lung development from 10 to 18 years of age', New England Journal of Medicine, vol. 351, no. 11, pp. 1057-1067. https://doi.org/10.1056/NEJMoa040610
Gauderman WJ, Avol E, Gilliland F, Vora H, Thomas D, Berhane K et al. The effect of air pollution on lung development from 10 to 18 years of age. New England Journal of Medicine. 2004 Sep 9;351(11):1057-1067. https://doi.org/10.1056/NEJMoa040610
Gauderman, W. James ; Avol, Edward ; Gilliland, Frank ; Vora, Hita ; Thomas, Duncan ; Berhane, Kiros ; McConnell, Rob ; Kuenzli, Nino ; Lurmann, Fred ; Rappaport, Edward ; Margolis, Helene G ; Bates, David ; Peters, John. / The effect of air pollution on lung development from 10 to 18 years of age. In: New England Journal of Medicine. 2004 ; Vol. 351, No. 11. pp. 1057-1067.
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abstract = "BACKGROUND: Whether exposure to air pollution adversely affects the growth of lung function during the period of rapid lung development that occurs between the ages of 10 and 18 years is unknown. METHODS: In this prospective study, we recruited 1759 children (average age, 10 years) from schools in 12 southern California communities and measured lung function annually for eight years. The rate of attrition was approximately 10 percent per year. The communities represented a wide range of ambient exposures to ozone, acid vapor, nitrogen dioxide, and particulate matter. Linear regression was used to examine the relationship of air pollution to the forced expiratory volume in one second (FEV1) and other spirometric measures. RESULTS: Over the eight-year period, deficits in the growth of FEV1 were associated with exposure to nitrogen dioxide (P=0.005), acid vapor (P=0.004), particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) (P=0.04), and elemental carbon (P=0.007), even after adjustment for several potential confounders and effect modifiers. Associations were also observed for other spirometric measures. Exposure to pollutants was associated with clinically and statistically significant deficits in the FEV1 attained at the age of 18 years. For example, the estimated proportion of 18-year-old subjects with a low FEV1 (defined as a ratio of observed to expected FEV1 of less than 80 percent) was 4.9 times as great at the highest level of exposure to PM2.5 as at the lowest level of exposure (7.9 percent vs. 1.6 percent, P=0.002). CONCLUSIONS: The results of this study indicate that current levels of air pollution have chronic, adverse effects on lung development in children from the age of 10 to 18 years, leading to clinically significant deficits in attained FEV1 as children reach adulthood.",
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AU - Avol, Edward

AU - Gilliland, Frank

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AU - Thomas, Duncan

AU - Berhane, Kiros

AU - McConnell, Rob

AU - Kuenzli, Nino

AU - Lurmann, Fred

AU - Rappaport, Edward

AU - Margolis, Helene G

AU - Bates, David

AU - Peters, John

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N2 - BACKGROUND: Whether exposure to air pollution adversely affects the growth of lung function during the period of rapid lung development that occurs between the ages of 10 and 18 years is unknown. METHODS: In this prospective study, we recruited 1759 children (average age, 10 years) from schools in 12 southern California communities and measured lung function annually for eight years. The rate of attrition was approximately 10 percent per year. The communities represented a wide range of ambient exposures to ozone, acid vapor, nitrogen dioxide, and particulate matter. Linear regression was used to examine the relationship of air pollution to the forced expiratory volume in one second (FEV1) and other spirometric measures. RESULTS: Over the eight-year period, deficits in the growth of FEV1 were associated with exposure to nitrogen dioxide (P=0.005), acid vapor (P=0.004), particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) (P=0.04), and elemental carbon (P=0.007), even after adjustment for several potential confounders and effect modifiers. Associations were also observed for other spirometric measures. Exposure to pollutants was associated with clinically and statistically significant deficits in the FEV1 attained at the age of 18 years. For example, the estimated proportion of 18-year-old subjects with a low FEV1 (defined as a ratio of observed to expected FEV1 of less than 80 percent) was 4.9 times as great at the highest level of exposure to PM2.5 as at the lowest level of exposure (7.9 percent vs. 1.6 percent, P=0.002). CONCLUSIONS: The results of this study indicate that current levels of air pollution have chronic, adverse effects on lung development in children from the age of 10 to 18 years, leading to clinically significant deficits in attained FEV1 as children reach adulthood.

AB - BACKGROUND: Whether exposure to air pollution adversely affects the growth of lung function during the period of rapid lung development that occurs between the ages of 10 and 18 years is unknown. METHODS: In this prospective study, we recruited 1759 children (average age, 10 years) from schools in 12 southern California communities and measured lung function annually for eight years. The rate of attrition was approximately 10 percent per year. The communities represented a wide range of ambient exposures to ozone, acid vapor, nitrogen dioxide, and particulate matter. Linear regression was used to examine the relationship of air pollution to the forced expiratory volume in one second (FEV1) and other spirometric measures. RESULTS: Over the eight-year period, deficits in the growth of FEV1 were associated with exposure to nitrogen dioxide (P=0.005), acid vapor (P=0.004), particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) (P=0.04), and elemental carbon (P=0.007), even after adjustment for several potential confounders and effect modifiers. Associations were also observed for other spirometric measures. Exposure to pollutants was associated with clinically and statistically significant deficits in the FEV1 attained at the age of 18 years. For example, the estimated proportion of 18-year-old subjects with a low FEV1 (defined as a ratio of observed to expected FEV1 of less than 80 percent) was 4.9 times as great at the highest level of exposure to PM2.5 as at the lowest level of exposure (7.9 percent vs. 1.6 percent, P=0.002). CONCLUSIONS: The results of this study indicate that current levels of air pollution have chronic, adverse effects on lung development in children from the age of 10 to 18 years, leading to clinically significant deficits in attained FEV1 as children reach adulthood.

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