The effect of aging on T-regulatory cell frequency in HIV infection

Allan R. Tenorio, John Spritzler, Jeffrey Martinson, Caroline N. Gichinga, Richard B Pollard, Michael M. Lederman, Robert C. Kalayjian, Alan L. Landay

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

T-regulatory cell (T-reg) frequency is increased in HIV infection and with aging. We evaluated the effect of age on total, memory and naïve T-reg percentages in untreated HIV infection. Older HIV+ subjects had a total T-reg percent that is 2.8% (p = 0.02) higher than among younger HIV+, older HIV- and younger HIV- subjects. In HIV+ subjects, the total T-reg percentage is inversely correlated with the lymphocyte proliferative responses to tetanus (r = - 0.45, p = 0.002) and Candida (r = - 0.43, p = 0.003) antigens. Similar correlations were seen between memory T-reg percentages and the lymphocyte proliferative response to tetanus and Candida in HIV+ subjects. T-reg percentages did not correlate consistently with markers of immune activation. T-reg percentages are increased in the older HIV+ population and may play a role in the accelerated disease progression seen in older HIV-infected persons.

Original languageEnglish (US)
Pages (from-to)298-303
Number of pages6
JournalClinical Immunology
Volume130
Issue number3
DOIs
StatePublished - Mar 2009

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Regulatory T-Lymphocytes
HIV Infections
HIV
Tetanus
Candida
Lymphocytes
Disease Progression
Biomarkers
Antigens
Population

Keywords

  • Aging
  • HIV
  • T-regulatory cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Tenorio, A. R., Spritzler, J., Martinson, J., Gichinga, C. N., Pollard, R. B., Lederman, M. M., ... Landay, A. L. (2009). The effect of aging on T-regulatory cell frequency in HIV infection. Clinical Immunology, 130(3), 298-303. https://doi.org/10.1016/j.clim.2008.10.001

The effect of aging on T-regulatory cell frequency in HIV infection. / Tenorio, Allan R.; Spritzler, John; Martinson, Jeffrey; Gichinga, Caroline N.; Pollard, Richard B; Lederman, Michael M.; Kalayjian, Robert C.; Landay, Alan L.

In: Clinical Immunology, Vol. 130, No. 3, 03.2009, p. 298-303.

Research output: Contribution to journalArticle

Tenorio, AR, Spritzler, J, Martinson, J, Gichinga, CN, Pollard, RB, Lederman, MM, Kalayjian, RC & Landay, AL 2009, 'The effect of aging on T-regulatory cell frequency in HIV infection', Clinical Immunology, vol. 130, no. 3, pp. 298-303. https://doi.org/10.1016/j.clim.2008.10.001
Tenorio AR, Spritzler J, Martinson J, Gichinga CN, Pollard RB, Lederman MM et al. The effect of aging on T-regulatory cell frequency in HIV infection. Clinical Immunology. 2009 Mar;130(3):298-303. https://doi.org/10.1016/j.clim.2008.10.001
Tenorio, Allan R. ; Spritzler, John ; Martinson, Jeffrey ; Gichinga, Caroline N. ; Pollard, Richard B ; Lederman, Michael M. ; Kalayjian, Robert C. ; Landay, Alan L. / The effect of aging on T-regulatory cell frequency in HIV infection. In: Clinical Immunology. 2009 ; Vol. 130, No. 3. pp. 298-303.
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