The effect of aging on T-regulatory cell frequency in HIV infection

Allan R. Tenorio, John Spritzler, Jeffrey Martinson, Caroline N. Gichinga, Richard B Pollard, Michael M. Lederman, Robert C. Kalayjian, Alan L. Landay

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

T-regulatory cell (T-reg) frequency is increased in HIV infection and with aging. We evaluated the effect of age on total, memory and naïve T-reg percentages in untreated HIV infection. Older HIV+ subjects had a total T-reg percent that is 2.8% (p = 0.02) higher than among younger HIV+, older HIV- and younger HIV- subjects. In HIV+ subjects, the total T-reg percentage is inversely correlated with the lymphocyte proliferative responses to tetanus (r = - 0.45, p = 0.002) and Candida (r = - 0.43, p = 0.003) antigens. Similar correlations were seen between memory T-reg percentages and the lymphocyte proliferative response to tetanus and Candida in HIV+ subjects. T-reg percentages did not correlate consistently with markers of immune activation. T-reg percentages are increased in the older HIV+ population and may play a role in the accelerated disease progression seen in older HIV-infected persons.

Original languageEnglish (US)
Pages (from-to)298-303
Number of pages6
JournalClinical Immunology
Volume130
Issue number3
DOIs
StatePublished - Mar 2009

Keywords

  • Aging
  • HIV
  • T-regulatory cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Fingerprint Dive into the research topics of 'The effect of aging on T-regulatory cell frequency in HIV infection'. Together they form a unique fingerprint.

  • Cite this

    Tenorio, A. R., Spritzler, J., Martinson, J., Gichinga, C. N., Pollard, R. B., Lederman, M. M., Kalayjian, R. C., & Landay, A. L. (2009). The effect of aging on T-regulatory cell frequency in HIV infection. Clinical Immunology, 130(3), 298-303. https://doi.org/10.1016/j.clim.2008.10.001