The effect of adrenergic agonists and cyclic AMP on the Na+/K+ ATPase activity of brown adipose tissue

Barbara A Horwitz, Martha Eaton

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The Na+/K+ ATPase activity of membrane fractions prepared from brown adipose tissue of cold-acclimated rats could be stimulated by addition of any one of the following: norepinephrine, isoproterenol, cyclic AMP or phenylephrine. These results are consistent with the proposal that in the intact brown adipocyte, the norepinephrine-induced stimulation of the Na+/K+ membrane pump is associated with α- as well as β-adrenergic pathways and is, in part, mediated via cyclic AMP.

Original languageEnglish (US)
Pages (from-to)241-245
Number of pages5
JournalEuropean Journal of Pharmacology
Volume34
Issue number1
DOIs
StatePublished - 1975

Keywords

  • Brown adipose tissue
  • Catecholamines
  • Cyclic AMP
  • Na/K membrane ATPase
  • Norepinephrine
  • α-Adrenergic agonists
  • β-Adrenergic agonists

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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