The effect of acipimox on triacylglycerol metabolism in rat

A. Al-Shurbajik, Lars Berglund

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The mechanism behind the hypolipidaemic effect of the drug Acipimox was studied in rat. The triacylglycerol (TG) lowering effect of the drug was accompanied by a marked reduction in free fatty acid (FFA) levels in the plasma. Also, the flux of TG from the liver to the plasma was substantially reduced. The liver TG content was not significantly changed. No significant effect of Acipimox treatment on the activities of glycerol 3-phosphate acyltransferase, phosphatidate phosphohydrolase or diacylglycerol acyltransferase in rat liver was observed. These findings strongly support the contention that Acipimox exerts its TG-low-ering effect mainly by reducing FFA influx to the liver and thereby reducing the de novo biosynthesis of TG in the liver.

Original languageEnglish (US)
Pages (from-to)203-208
Number of pages6
JournalScandinavian Journal of Clinical and Laboratory Investigation
Volume50
Issue number2
DOIs
StatePublished - 1990
Externally publishedYes

Keywords

  • Acipimox
  • Free fatty acids
  • Hypolipidemic drug
  • Phosphatidate phosphohydrolase
  • Triacylglycerol secretion
  • Triacylglycerol synthesis

ASJC Scopus subject areas

  • Clinical Biochemistry

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