The effect of a glycine derivative (CP 1552 S) on the aquisition of kindled amygdaloid seizures in rats

The effects of CP 1552 S (2-N-pentylaminoacetamide hydrochloride) at three dosage levels (30, 100, 300 mg/kg) were evaluated for potential anticonvulsant activity in a group of 60 male Sprague-Dawley rats. The rats were surgically implanted with cortical and amygdaloid electrodes, housed individually and assigned randomly to control and treatment groups. Drug solutions were prepared immediately prior to use and i.p. injections (lcc/kg) were given 1 hour prior to daily stimulation of the amygdala (1 sec train of 60 Hz, biphasic pulses, 1 msec duration, 400 μA constant current) for a total of 17 days. The afterdischarge duration (AD, secs) and behavioral response (BR, scale of 0 to 5) were noted following each stimulation. Results indicated that there was no statistically significant change in the BR of any treatment group compared to the controls on any day. The AD values were significantly different (P ≤ .05) from control for the 30 mg/kg treatment group on day 17 and for the 300 mg/kg treatment group on days 12, 16, and 17. It is concluded that this substance has little or no consistent anticonvulsant activity against the acquisition or expression of kindled amygdaloid seizures.