The effect of 5-fluorouracil and adriamycin on heterotransplantation of noble rat prostatic tumors in congenitally athymic (nude) mice

J. R. Drago, R. E. Maurer, M. Eric Gershwin, D. Eckels, J. M. Palmer

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6 Scopus citations


The Nb rat prostatic adenocarcinoma is a well-characterized, hormonally induced family of tumors that are all readily transplantable into congenitally athymic (nude) mice. Because of this versatile heterotransplantation model, multiple replicate copies of individual tumors can be studied 'in rodent'. rodent . The authors extended this by studying the chemotherapeutic response of such tumors and believe that this provides a useful avenue for evaluation of cytotoxic agents. Indeed, this combination of both animal model systems may provide a useful experimental tool to evaluate tumor growth, histopathologic changes and responsiveness to appropriate therapy. The authors report herein that two Nb rat prostatic carcinomas (2 Pr-129-D-11A and Pr-90) and their responsiveness to Adriamycin and 5-fluorouracil are objective by studying both growth rates and tumor histology.

Original languageEnglish (US)
Pages (from-to)424-430
Number of pages7
Issue number2
StatePublished - 1979


ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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