The effect of Δ1-testolactone on serum testosterone and estradiol in the adult male rat

H. M. Nagler, Ralph W deVere White, I. Dyrenfurth, W. C. Hembree

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Δ1-Testolactone, an androgen derivative without intrinsic hormonal action, is known to block the aromatization of androgens to estrogens. This study was designed to assess its effect upon serum testosterone (T) and estradiol (E2) in the adult male rat. By itself, testolactone (TL) did not affect T/E2 levels in the dosages utilized. Daily injections of human chorionic gonadotropin (hCG) for 15 days caused a tenfold rise in serum T, although there was no increase in serum E2. When given along with hCG, TL did not alter the Leydig cell response. However, pretreatment of animals with TL increased the testicular response to hCG over that of saline-treated animals. Studies were also carried out to delineate the sources of estrogen in the adult male rat. These experiments demonstrate that (1) the majority of E2 is not testicular in origin but is derived from the adrenal; (2) the conversion of androgen precursors to E2 in the rat is not affected by TL; and (3) in spite of no demonstrable inhibition of E2 production, TL causes an increased Leydig cell responsiveness to hCG.

Original languageEnglish (US)
Pages (from-to)818-822
Number of pages5
JournalFertility and Sterility
Volume40
Issue number6
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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