The effect of α-Tocopherol on monocyte proatherogenic activity

Ishwarlal Jialal, Sridevi Devaraj, Nalini Kaul

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

Atherosclerosis is the leading cause of morbidity and mortality in Westernized populations. The monocyte is a crucial cell in the genesis of the atherosclerotic lesion and is present during all stages of atherosclerosis. α-Tocopherol (AT) is the most active component of the vitamin E family and is the principal and most potent lipid-soluble antioxidant in plasma and LDL. With regard to monocyte function, AT supplementation (1200 iu/d) has been shown to decrease release of reactive oxygen species, lipid oxidation, release of cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) and decrease adhesion of monocytes to human endothelium. The mechanism of inhibition of superoxide and lipid oxidation by monocytes appears to be via inhibition of protein kinase C (PKC), the decrease in IL-1β and TNF-α release by inhibition of 5-lipoxygenase and the inhibition of monocyte-endothelial cell adhesion via decrease in adhesion molecules on monocytes, CD11b and VLA-4 and by decreasing DNA-binding activity of nuclear transcription factor κB. Thus, in addition to the decrease in oxidative stress resulting from AT supplementation, as evidenced by decreased F2-isoprostanes and LDL oxidizability, AT is anti-inflammatory and exerts beneficial antiatherogenic effects on cells crucial in atherogenesis such as monocytes.

Original languageEnglish (US)
JournalJournal of Nutrition
Volume131
Issue number2
StatePublished - 2001
Externally publishedYes

Keywords

  • α-tocopherol
  • Antioxidant
  • Inflammation
  • Monocytes
  • Vitamin E

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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