The dynamics of the skin’s immune system

Alan V. Nguyen, Athena M. Soulika

Research output: Contribution to journalReview articlepeer-review

111 Scopus citations


The skin is a complex organ that has devised numerous strategies, such as physical, chemical, and microbiological barriers, to protect the host from external insults. In addition, the skin contains an intricate network of immune cells resident to the tissue, crucial for host defense as well as tissue homeostasis. In the event of an insult, the skin-resident immune cells are crucial not only for prevention of infection but also for tissue reconstruction. Deregulation of immune responses often leads to impaired healing and poor tissue restoration and function. In this review, we will discuss the defensive components of the skin and focus on the function of skin-resident immune cells in homeostasis and their role in wound healing.

Original languageEnglish (US)
Article number1811
JournalInternational journal of molecular sciences
Issue number8
StatePublished - Apr 2 2019


  • Impaired wound healing
  • Inflammation
  • Scarring
  • Skin immune responses
  • Skin resident immune cells
  • Wound healing

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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